Coagulation Factor XIV/Protein C Antibody (PC107)

Product Discontinued

Coagulation Factor XIV/Protein C Antibody (PC107) Summary

• Immunogen: Human protein C.
• Specificity: Monoclonal antibody PC107 is specific for activated Protein C (APC).
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Rat
• Gene: PROC
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunoassay
  • Western Blot 1:50

Reactivity Notes

Human.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: 0.2 um filtered solution in PBS and 0.1% BSA
• Preservative: 0.02% Sodium Azide
• Purity: Protein A or G purified

Alternate Names for Coagulation Factor XIV/Protein C Antibody (PC107)

• Anticoagulant protein C
• APC
• Autoprothrombin IIA
• Blood coagulation factor XIV
• Coagulation Factor XIV
• EC 3.4.21
• EC 3.4.21.69
• PC
• PROC
• PROC1
• protein C (inactivator of coagulation factors Va and VIIIa)
• Protein C
• vitamin K-dependent protein C

Background

Monoclonal antibody PC107 is specific for activated Protein C (APC). Protein C (PC) is an important regulator of the blood coagulation system. The anticoagulant PC is converted to activated protein C (APC) by the thrombomodulin (TM)-thrombin complex on the phospholipid surface of endothelial cells, monocytes, and platelets. This process is enhanced in the presence of the endothelial protein C receptor (EPCR). In addition to its regulatory function in the blood coagulation system, studies indicate important roles for APC in inflammatory processes. The administration of APC prevents lethal effects of Escherichia coli-associated sepsis in experimental animal models and appears effective for the treatment of patients with meningococcemia or acquired PC deficiency. Treatment with APC improves the clinical outcome of patients with sepsis. The anti-inflammatory activity of APC depends on its ability to suppress the secretion of cytokines as tumor necrosis factor-alpha by inflammatory cells, the activation and extravasation of leukocytes and the expression and function of adhesion molecules. APC may also suppress the expression of growth factors and members of nuclear factor-kB (NF-kB) family of transcription factors. The monoclonal antibody PC107 is specific for activated human protein C (APC) and it lacks reactivity for Protein C. The monoclonal antibody recognizes the light chain of the APC molecule.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PROC
• Entrez:
  • 5624(Human)