Coagulation Factor XIV/Protein C Antibody (3C7) [Alexa Fluor® 647]

Product Discontinued

Coagulation Factor XIV/Protein C Antibody (3C7) [Alexa Fluor® 647] Summary

• Immunogen: Protein C isolated from human plasma and adsorbed onto aluminum hydroxide gel.
• Epitope: Epitope specificity differs from that of Clone 01
• Specificity: Clone 3C7 reacts with human protein C
• Isotype: IgG2b Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: PROC
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Human

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Alternate Names for Coagulation Factor XIV/Protein C Antibody (3C7) [Alexa Fluor® 647]

• Anticoagulant protein C
• APC
• Autoprothrombin IIA
• Blood coagulation factor XIV
• Coagulation Factor XIV
• EC 3.4.21
• EC 3.4.21.69
• PC
• PROC
• PROC1
• protein C (inactivator of coagulation factors Va and VIIIa)
• Protein C
• vitamin K-dependent protein C

Background

Protein C is a vitamin K-dependent serine protease that is produced in the liver and made up of 2 polypeptide chains. The 62 kDa proenzyme is activated by thrombin bound to an endothelial surface receptor and the active enzyme cleaves factor Va and VIIIa inhibiting blood coagulation. The molecular weight of the active enzyme is 55 kDa and the normal concentration in human plasma is approximately 1-3 ng/ml while the concentration of the proenzyme is approximately 3 ug/mL due to the very fast turnover.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PROC