CLIP170 Antibody

Images

 
Western Blot: CLIP170 Antibody [NBP1-76921] - Rat brain tissue lysate with CLIP170 antibody at (A) 0.5 and (B) 1 ug/ml.
Immunocytochemistry/ Immunofluorescence: CLIP170 Antibody [NBP1-76921] - Immunofuorescence of CLIP170 in human brain tissue with CLIP170 antibody at 20 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

CLIP170 Antibody Summary

Immunogen
Antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human CLIP170. The immunogen is located within amino acids 1340 - 1390 of CLIP170.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CLIP1
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 0.5-1 ug/ml
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 20 ug/ml
Control Peptide
CLIP170 Peptide (NBP1-76921PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CLIP170 Antibody

  • CAP-GLY domain containing linker protein 1
  • CLIP
  • CLIP170
  • CLIP-170Reed-Sternberg intermediate filament-associated protein
  • CYLN1MGC131604
  • cytoplasmic linker 1
  • Cytoplasmic linker protein 1
  • Cytoplasmic linker protein 170 alpha-2
  • Reed-Steinberg cell-expressed intermediate filament-associated protein
  • restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)
  • Restin
  • RSNCAP-Gly domain-containing linker protein 1

Background

CLIP170 was initially identified as a new type of intermediate filament associated protein that is highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkin's disease. Later experiments showed that it is located at microtubule plus ends and is required for the binding of endocytic carrier vesicles. CLIP170 has also been suggested to act with LIS1, a protein implicated in brain development, to regulate dynein/dynactin binding microtubules. Other studies suggest that CLIP170 can influence the formation of lamellipodia and cell invasion by invasive breast cancer cells by regulating the release of kinesin and IQGAP1 from a complex of those proteins, CLIP170 and Rac1. At least two isoforms of CLIP170 are known to exist.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol CLIP1
Uniprot