CLIP170 Antibody - BSA Free

Western Blot: CLIP170 Antibody [NBP1-76921] - Rat brain tissue lysate with CLIP170 antibody at (A) 0.5 and (B) 1 ug/ml.

Immunocytochemistry/ Immunofluorescence: CLIP170 Antibody - BSA Free [NBP1-76921] - Immunofuorescence of CLIP170 in human brain tissue with CLIP170 antibody at 20 ug/mL.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, ICC/IF
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

CLIP170 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit CLIP170 Antibody - BSA Free (NBP1-76921) is a polyclonal antibody validated for use in WB, ELISA and ICC/IF. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human CLIP170. The immunogen is located within amino acids 1340 - 1390 of CLIP170. Amino Acid Squence: CNNYDSDDQEKQSKKKPR
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CLIP1
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 20 ug/ml
  • Western Blot 0.5-1 ug/ml
• Control Peptide:

  CLIP170 Peptide (NBP1-76921PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for CLIP170 Antibody - BSA Free

• CAP-GLY domain containing linker protein 1
• CLIP
• CLIP170
• CLIP-170Reed-Sternberg intermediate filament-associated protein
• CYLN1MGC131604
• cytoplasmic linker 1
• Cytoplasmic linker protein 1
• Cytoplasmic linker protein 170 alpha-2
• Reed-Steinberg cell-expressed intermediate filament-associated protein
• restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)
• Restin
• RSNCAP-Gly domain-containing linker protein 1

Background

CLIP170 was initially identified as a new type of intermediate filament associated protein that is highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkin's disease. Later experiments showed that it is located at microtubule plus ends and is required for the binding of endocytic carrier vesicles. CLIP170 has also been suggested to act with LIS1, a protein implicated in brain development, to regulate dynein/dynactin binding microtubules. Other studies suggest that CLIP170 can influence the formation of lamellipodia and cell invasion by invasive breast cancer cells by regulating the release of kinesin and IQGAP1 from a complex of those proteins, CLIP170 and Rac1. At least two isoforms of CLIP170 are known to exist.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CLIP1
• Uniprot:
  • NP_002947(Human)