Claudin-3 Antibody (385021) [Unconjugated]

Images

 
Claudin‑3 was detected in immersion fixed paraffin-embedded sections of human colon array using Mouse Anti-Human Claudin‑3 Monoclonal Antibody (Catalog # MAB4620) at 15 µg/mL overnight at 4 °C. Tissue was stained ...read more
Claudin‑3 was detected in immersion fixed PC‑3 human prostate cancer cell line using Mouse Anti-Human Claudin‑3 Monoclonal Antibody (Catalog # MAB4620) at 10 µg/mL for 3 hours at room temperature. Cells were ...read more
PC‑3 human prostate cancer cell line was stained with Mouse Anti-Human Claudin‑3 Monoclonal Antibody (Catalog # MAB4620, filled histogram) or isotype control antibody (Catalog # MAB003, open histogram), followed by ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, IHC, CyTOF-ready, ICC/IF
Clone
385021
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Claudin-3 Antibody (385021) [Unconjugated] Summary

Immunogen
HEK293 human embryonic kidney cell line transfected with human Claudin-3
Met1-Val220
Accession # O15551
Specificity
Stains human Claudin-3 transfectants but not irrelevant transfectants.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
CLDN3
Purity
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 2.5 ug/10^6 cells
  • Immunohistochemistry 8-25 ug/mL
  • CyTOF-ready
  • Immunocytochemistry 8-25 ug/mL
Publications
Read Publication using
MAB4620 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS and NaCl with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A or G purified from hybridoma culture supernatant
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Claudin-3 Antibody (385021) [Unconjugated]

  • C7orf1
  • claudin 3
  • Claudin3
  • Claudin-3
  • CLDN3
  • Clostridium perfringens enterotoxin receptor 2
  • CPE-R 2
  • CPE-R2
  • CPETR2
  • CPETR2CPE-receptor 2
  • HRVP1
  • Rat ventral prostate.1 protein homolog
  • RVP1
  • ventral prostate.1 protein homolog
  • ventral prostate.1-like protein

Background

Claudin-3 is a 23 kDa multipass membrane protein in the claudin family of epithelial tight junction proteins. Claudin-3 is upregulated by EGF and in inflammation and a variety of epithelial cancers. Its expression is lost in the blood brain barrier during pathological disruptions of that structure. Claudin-3 binding to the Clostridium perfringes exotoxin induces epithelial cell lysis. Human Claudin-3 shares 91% amino acid sequence identity with mouse and rat Claudin-3.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Claudin-3 Antibody (MAB4620)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Antibody Profiling.


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Antibody Profiling
(1)
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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 FAB4620U
Alexa Fluor 405 FAB4620V
Alexa Fluor 488 FAB4620G
Alexa Fluor 594 FAB4620T
Alexa Fluor 647 FAB4620R
Alexa Fluor 700 FAB4620N
Alexa Fluor 750 FAB4620S
Allophycocyanin FAB4620A
Fluorescein FAB4620F
Phycoerythrin FAB4620P

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Bioinformatics Tool for Claudin-3 Antibody (MAB4620)

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Bioinformatics

Gene Symbol CLDN3
Uniprot