Claudin-3 Antibody (385021) [Fluorescein]

PC-3 human prostate cancer cell line was stained with Mouse Anti-Human Claudin-3 Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB4620F, filled histogram) or isotype control antibody (Catalog # IC003F, open histogram). View our protocol for Staining Membrane-associated Proteins.

• Reactivity: Hu
• Applications: Flow
• Clone: 385021
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Fluorescein

Claudin-3 Antibody (385021) [Fluorescein] Summary

• Immunogen: HEK293 human embryonic kidney cell line transfected with human Claudin-3
  Met1-Val220
  Accession # O15551
• Specificity: Stains human Claudin-3 transfectants but not irrelevant transfectants.
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: CLDN3
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Claudin-3 Antibody (385021) [Fluorescein]

• C7orf1
• claudin 3
• Claudin3
• Claudin-3
• CLDN3
• Clostridium perfringens enterotoxin receptor 2
• CPE-R 2
• CPE-R2
• CPETR2
• CPETR2CPE-receptor 2
• HRVP1
• Rat ventral prostate.1 protein homolog
• RVP1
• ventral prostate.1 protein homolog
• ventral prostate.1-like protein

Background

Claudin-3 is a 23 kDa multipass membrane protein in the claudin family of epithelial tight junction proteins. Claudin-3 is upregulated by EGF and in inflammation and a variety of epithelial cancers. Its expression is lost in the blood brain barrier during pathological disruptions of that structure. Claudin-3 binding to the Clostridium perfringes exotoxin induces epithelial cell lysis. Human Claudin-3 shares 91% amino acid sequence identity with mouse and rat Claudin-3.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CLDN3
• Uniprot:
  • O15551()