Chromogranin A Antibody (CGA/413)

Images

 
Immunohistochemistry-Paraffin: Chromogranin A Antibody (CGA/413) [NBP2-44776] - Human Pheochromocytoma stained with Chromogranin A Monoclonal Antibody (CGA/413)
Immunohistochemistry-Paraffin: Chromogranin A Antibody (CGA/413) [NBP2-44776] - Human Adrenal Gland stained with Chromogranin A Monoclonal Antibody (CGA/413)
Immunohistochemistry-Paraffin: Chromogranin A Antibody (CGA/413) [NBP2-44776] - Human Pancreas stained with Chromogranin A Monoclonal Antibody (CGA/413)
Immunohistochemistry-Paraffin: Chromogranin A Antibody (CGA/413) [NBP2-44776] - Human Parathyroid stained with Chromogranin A Monoclonal Antibody (CGA/413)
Protein Array: Chromogranin A Antibody (CGA/413) [NBP2-44776] - Analysis of Protein Array containing more than 19,000 full-length human proteins using Chromogranin A antibody (CGA/413)

Product Details

Summary
Reactivity Hu, Rt(-)Species Glossary
Applications IHC, IHC-P, PA
Clone
CGA/413
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.2 mg/ml

Order Details

Chromogranin A Antibody (CGA/413) Summary

Immunogen
Recombinant full-length human Chromogranin A protein (Uniprot: P10645)
Localization
Finely granular cytoplasmic
Marker
Neuroendocrine Marker
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
CHGA
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 0.25-0.5 ug/ml
  • Protein Array
Application Notes
Immunohistochemistry (Formalin-fixed): 0.25-0.5ug/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes.
Optimal dilution for a specific application should be determined.

Reactivity Notes

Does not react with Rat.

Packaging, Storage & Formulations

Storage
Store at 4C.
Buffer
10 mM PBS with 0.05% BSA
Preservative
0.05% Sodium Azide
Concentration
0.2 mg/ml
Purity
Protein A or G purified

Notes

200ug/ml of antibody purified from Bioreactor Concentrate by Protein A or G. Prepared in 10 mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0 mg/ml. (NBP2-47850)

Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80C. Antibody is stable for 24 months. Non-hazardous.

Alternate Names for Chromogranin A Antibody (CGA/413)

  • betagranin (N-terminal fragment of chromogranin A)
  • Betagranin
  • Catestatin
  • CGA
  • CHGA
  • Chromofungin
  • chromogranin A (parathyroid secretory protein 1)
  • Chromogranin A
  • chromogranin-A
  • Pancreastatin
  • Parastatin
  • Parathyroid Secretory Protein 1
  • Pituitary Secretory Protein I
  • SP-I

Background

Chromogranin A (CgA) is an 86 kDa protein that is the major member of the granin family of acidic secretory glycoproteins located in neuroendocrine cells. CgA is believed to play a role in targeting peptide hormones and neurotransmitters to granules of the regulated pathways and inhibit hormone and neurotransmitter release. Also, the widespread distribution of CgA has made the measurement of circulating immunoreactive CgA a valuable tool in the diagnosis of neuroendocrine neoplasia, and CgA immunohistochemistry can help to identify the neuroendocrine nature of tumors. The N-terminal domain of CgA inhibits tumor necrosis factor a (TNFa) induced gap formation in human umbilical venous endothelial cells. CgA levels which reflect neuroendocrine differentiation of prostatic carcinoma may have a diagnostic, therapeutic and prognostic role in the management of prostate cancer patients.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs for Chromogranin A Antibody (NBP2-44776). (Showing 1 - 1 of 1 FAQ).

  1. I have following question about antibodies against Chromogranin A. Your products list the species but canine is not included. Does it mean that the products cannot be used on canine tissues?
    • When we do not list a species, it means we have not tested an antibody to work with those samples. If we test an antibody and find that it does not work, we will list the species with a minus sign. Unfortunately, we haven't tried these abs on canine tissues and they may work, but we cannot guarantee it. If you would like to purchase one to try, you will be eligible for the Innovators Reward Program.

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Bioinformatics

Gene Symbol CHGA
Uniprot