Hu, Mu, RtApplications:
ICC/IF, IHC, IHC-PHost:
WB, ELISA, IHC, IHC-P, PAGEHost:
Applications: IHC, IHC-P
Host: Rabbit Monoclonal
Applications: WB, ELISA, PA
Applications: RNAi, RNAi SP
Chromogranin A (CgA) is an 86 kDa protein that is the major member of the granin family of acidic secretory glycoproteins located in neuroendocrine cells. CgA is believed to play a role in targeting peptide hormones and neurotransmitters to granules of the regulated pathways and inhibit hormone and neurotransmitter release. Also, the widespread distribution of CgA has made the measurement of circulating immunoreactive CgA a valuable tool in the diagnosis of neuroendocrine neoplasia, and CgA immunohistochemistry can help to identify the neuroendocrine nature of tumors. The N-terminal domain of CgA inhibits tumor necrosis factor a (TNFa) induced gap formation in human umbilical venous endothelial cells. CgA levels which reflect neuroendocrine differentiation of prostatic carcinoma may have a diagnostic, therapeutic and prognostic role in the management of prostate cancer patients.
Bioinformatics Tool for Chromogranin A
Discover related pathways, diseases and genes to Chromogranin A. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.