CEACAM7 Antibody (962720) [Unconjugated] Summary
Immunogen |
Chinese Hamster Ovary cell line, CHO-derived recombinant human CEACAM-7 Thr36-Asn233 Accession # Q14002 |
Specificity |
Detects human CEACAM-7 in direct ELISAs. |
Source |
N/A |
Isotype |
IgG1 |
Clonality |
Monoclonal |
Host |
Mouse |
Purity Statement |
Protein A or G purified from hybridoma culture supernatant |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- CyTOF-ready
- ELISA
- Flow Cytometry 0.25 ug/10^6 cells
- Immunohistochemistry 5-25 ug/mL
|
Packaging, Storage & Formulations
Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. - 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
|
Buffer |
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. |
Reconstitution Instructions |
Reconstitute at 0.5 mg/mL in sterile PBS. |
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for CEACAM7 Antibody (962720) [Unconjugated]
Background
Carcinoembryonic antigen-related cell adhesion molecule 7 (CEACAM-7), also known as CGM2, is an approximately 40 kDa GPI-anchored glycoprotein in the CEACAM family of adhesion molecules (1). Mature human CEACAM-7 consists of two Ig-like domains followed by the GPI anchor (2). Alternative splicing generates a short isoform that lacks the second Ig-like domain. CEACAM-7 is preferentially expressed on the luminal surface of epithelial cells near the mouth of colonic crypts and on pancreatic ductal epithelial cells (3, 4). It is down-regulated during colorectal adenoma progression (2-6) but can be up-regulated during the development of gastric carcinoma (7). R&D Systems in-house testing indicates that CEACAM-7 binds to CEACAM-1, consistent with the heterophilic interaction of CEACAM-1 with other CEACAM family members (1, 8, 9).
- Tchoupa, A.K. et al. (2014) Cell Commun. Signal. 12:27.
- Thompson, J. et al. (1994) J. Biol. Chem. 269:32924.
- Thompson, J. et al. (1997) Cancer Res. 57:1776.
- Scholzel, S. et al. (2000) Am. J. Pathol. 156:595.
- Nollau, P. et al. (1997) Cancer Res. 57:2354.
- Nollau, P. et al. (1997) Am. J. Pathol. 151:521.
- Zhou, J. et al. (2011) World J. Surgical Oncol. 9:172.
- Markel, G. et al. (2004) J. Immunol. 173:3732.
- Oikawa, S. et al. (1992) Biochem. Biophys. Res. Commun. 186:881.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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