CEACAM7 Antibody (962703) [Alexa Fluor® 750]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
962703
Clonality
Monoclonal
Host
Mouse
Conjugate
Alexa Fluor 750

CEACAM7 Antibody (962703) [Alexa Fluor® 750] Summary

Immunogen
Chinese Hamster Ovary cell line, CHO-derived recombinant human CEACAM-7
Thr36-Asn233
Accession # Q14002
Specificity
Detects human CEACAM-7 in direct ELISAs.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 0.25-1 ug/10^6 cells

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CEACAM7 Antibody (962703) [Alexa Fluor® 750]

  • Carcinoembryonic antigen CGM 2
  • Carcinoembryonic antigen CGM2
  • Carcinoembryonic antigen gene family member 2
  • Carcinoembryonic antigen related cell adhesion molecule 7
  • CEA
  • CEACAM 7
  • CEACAM7
  • CEACAM-7
  • CGM 2
  • CGM2

Background

Carcinoembryonic antigen-related cell adhesion molecule 7 (CEACAM-7), also known as CGM2, is an approximately 40 kDa GPI-anchored glycoprotein in the CEACAM family of adhesion molecules (1). Mature human CEACAM-7 consists of two Ig-like domains followed by the GPI anchor (2). Alternative splicing generates a short isoform that lacks the second Ig-like domain. CEACAM-7 is preferentially expressed on the luminal surface of epithelial cells near the mouth of colonic crypts and on pancreatic ductal epithelial cells (3, 4). It is down-regulated during colorectal adenoma progression (2-6) but can be up-regulated during the development of gastric carcinoma (7). R&D Systems in-house testing indicates that CEACAM-7 binds to CEACAM-1, consistent with the heterophilic interaction of CEACAM-1 with other CEACAM family members (1, 8, 9).
  1. Tchoupa, A.K. et al. (2014) Cell Commun. Signal. 12:27.
  2. Thompson, J. et al. (1994) J. Biol. Chem. 269:32924.
  3. Thompson, J. et al. (1997) Cancer Res. 57:1776.
  4. Scholzel, S. et al. (2000) Am. J. Pathol. 156:595.
  5. Nollau, P. et al. (1997) Cancer Res. 57:2354.
  6. Nollau, P. et al. (1997) Am. J. Pathol. 151:521.
  7. Zhou, J. et al. (2011) World J. Surgical Oncol. 9:172.
  8. Markel, G. et al. (2004) J. Immunol. 173:3732.
  9. Oikawa, S. et al. (1992) Biochem. Biophys. Res. Commun. 186:881.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 FAB44781U
Alexa Fluor 405 FAB44781V
Alexa Fluor 488 FAB44781G
Alexa Fluor 594 FAB44781T
Alexa Fluor 647 FAB44781R
Alexa Fluor 700 FAB44781N
Alexa Fluor 750 FAB44781S

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