CEACAM7 Antibody (962703) [Alexa Fluor™ Plus 594]

• Reactivity: Hu
• Clone: 962703
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 594

CEACAM7 Antibody (962703) [Alexa Fluor™ Plus 594] Summary

• Specificity: Detects human CEACAM-7 in direct ELISAs.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CEACAM7 Antibody (962703) [Alexa Fluor™ Plus 594]

• Carcinoembryonic antigen CGM 2
• Carcinoembryonic antigen CGM2
• Carcinoembryonic antigen gene family member 2
• Carcinoembryonic antigen related cell adhesion molecule 7
• CEA
• CEACAM 7
• CEACAM7
• CEACAM-7
• CGM 2
• CGM2

Background

Carcinoembryonic antigen-related cell adhesion molecule 7 (CEACAM-7), also known as CGM2, is an approximately 40 kDa GPI-anchored glycoprotein in the CEACAM family of adhesion molecules (1). Mature human CEACAM-7 consists of two Ig-like domains followed by the GPI anchor (2). Alternative splicing generates a short isoform that lacks the second Ig-like domain. CEACAM-7 is preferentially expressed on the luminal surface of epithelial cells near the mouth of colonic crypts and on pancreatic ductal epithelial cells (3, 4). It is down-regulated during colorectal adenoma progression (2-6) but can be up-regulated during the development of gastric carcinoma (7). R&D Systems in-house testing indicates that CEACAM-7 binds to CEACAM-1, consistent with the heterophilic interaction of CEACAM-1 with other CEACAM family members (1, 8, 9).

1. Tchoupa, A.K. et al. (2014) Cell Commun. Signal. 12:27.
2. Thompson, J. et al. (1994) J. Biol. Chem. 269:32924.
3. Thompson, J. et al. (1997) Cancer Res. 57:1776.
4. Scholzel, S. et al. (2000) Am. J. Pathol. 156:595.
5. Nollau, P. et al. (1997) Cancer Res. 57:2354.
6. Nollau, P. et al. (1997) Am. J. Pathol. 151:521.
7. Zhou, J. et al. (2011) World J. Surgical Oncol. 9:172.
8. Markel, G. et al. (2004) J. Immunol. 173:3732.
9. Oikawa, S. et al. (1992) Biochem. Biophys. Res. Commun. 186:881.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.