CDX2 Antibody (AMT28)

Images

 
Immunohistochemistry-Paraffin: CDX2 Antibody (AMT28) [NB100-699] - Human colon.
Immunohistochemistry-Paraffin: CDX2 Antibody (AMT28) [NB100-699] - Formalin fixed paraffin embedded human colon stained with Cdx2 antibody.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, IHC-P
Clone
AMT28
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

CDX2 Antibody (AMT28) Summary

Immunogen
Prokaryotic recombinant protein corresponding to the 180 amino acid N-terminal region of the human CDX2 molecule.
Localization
Nuclear
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
CDX2
Purity
Tissue culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:25-1:50
Application Notes
Immunohistochemistry (paraffin-embedded sections): ABC method with a suggested incubation period of 60 minutes at room temperature. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 1 mM EDTA buffer, pH 8.0 prior to immunostaining.
Positive Control
CDX2 Lysate (NBL1-09065)

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
No buffer
Preservative
0.05% Sodium Azide
Purity
Tissue culture supernatant

Alternate Names for CDX2 Antibody (AMT28)

  • caudal type homeo box transcription factor 2
  • caudal type homeobox 2
  • Caudal-type homeobox protein 2
  • CDX2
  • CDX3
  • CDX-3
  • CDX3caudal type homeobox transcription factor 2
  • homeobox protein CDX-2

Background

CDX2 is a caudal type homeobox gene that encodes an intestine-specific transcription factor that is expressed early in intestinal development and may be involved in the regulation of proliferation and differentiation of intestinal epithelial cells. It is expressed in the nuclei of epithelial cells throughout the intestine, from duodenum to rectum. The CDX2 protein is expressed in primary and metastatic colorectal carcinomas and has also been demonstrated in the intestinal metaplasia of the stomach and intestinal-type gastric cancer, while it is not expressed in the normal gastric mucosa. Studies have shown that CDX2 is superior marker compared to CK20.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol CDX2
Entrez
Uniprot