CDX2 Products

Description

The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear proteins that bind to specific sequences within the promoter of the insulin gene (INS; MIM 176730) and interact with RNA polymerase to activate or repress transcription. The proteins LMX1 (MIM 600298) and CDX3 are homeodomain proteins that bind an A/T-rich sequence in the insulin promoter and stimulate its transcription (German et al., 1994 [PubMed 7698771]).[supplied by OMIM]

Bioinformatics

Entrez	1045 Human 12591 Mouse 66019 Rat
Uniprot	AAH14461 Human AAH14461.1 Human NM_001265 Human NP_001256 Human Q99626 Human
Product By Gene ID	1045
Alternate Names	caudal type homeo box transcription factor 2 caudal type homeobox 2 Caudal-type homeobox protein 2 CDX-3 CDX3caudal type homeobox transcription factor 2 homeobox protein CDX-2

Research Areas for CDX2

Find related products by research area and learn more about each of the different research areas below.

Cancer
Chromatin Research
DNA Repair
Growth and Development
Transcription Factors and Regulators

Related CDX2 Blog Posts

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Stemness is responsible for onset and metastasis of colorectal cancer By Jamshed Arslan, Pharm. D., PhD. Colorectal cancer stem cells are a rare subpopulation of colorectal cancer cells that can self-renew and initiate and sustain tumor growth when transplanted into an animal host.1,2 C...    Read more.

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