CDR2 Antibody [Biotin]

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Product Details

Summary
Reactivity Hu, Mu, Bv, PmSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Biotin

CDR2 Antibody [Biotin] Summary

Immunogen
A synthetic peptide made to a C-terminal region of human CDR2 [Swiss-Prot# Q01850]
Localization
Cytoplasmic and Nuclear
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CDR2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
This CDR2 antibody is useful for Immunohistochemistry paraffin embedded sections, and Western blot analysis where a band is seen at ~51 kDa. Immunocytochemistry/Immunofluorescence was reported in scientific literature.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
51 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Readout System

Reactivity Notes

Human, mouse, bovine, primate. Immunogen has 85% homology to rat.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for CDR2 Antibody [Biotin]

  • CDR62
  • cerebellar degeneration-related protein (62kD)
  • cerebellar degeneration-related protein 2
  • cerebellar degeneration-related protein 2, 62kDa
  • Major Yo paraneoplastic antigen
  • Paraneoplastic cerebellar degeneration-associated antigen
  • PCD17
  • Yo paraneoplastic antigen
  • Yo

Background

Recent News: CDR2s Link to PCD (please find the link below). www.hhmi.org/news/darnell20071105.html Using anti-Yo antibodies, three genes have been cloned (CDR 1-3). CDR2 suppresses the transcriptional activity and DNA binding of nuclear factor-kappa B by an unknown mechanism. The neuron specific expression of CDR2 is regulated by a post-transcriptional mechanism.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Species: Hu, Mu, Bv, Pm
Applications: WB, ICC/IF, IHC, IHC-P

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for CDR2 Antibody (NB110-58345B). (Showing 1 - 2 of 2 FAQ).

  1. I'm looking for an antibody against human CDR2 to recognize thymic epithelial cells. You have several anti CDR2 antibodies. Are they against a thymic epithelial antigen or against the cerebellar degeneration-related protein 2, 62kDa?
    • Yes, the specific antibody you have inquired about is against cerebellar degeneration-related protein 2, 62 kDa. Moreover, all of our CDR2 primaries are against the same target.
  2. Do you have any further info regarding use of NB110-58345B in IHC? The customer is most interested to know if overnight incubation at 4C is recommended and also if the staining was performed using frozen or paraffin sections? Also, is any particular method of antigen retrieval recommended?
    • We typically recommend overnight incubation at 4C, but the customer could certainly try 1 hr at RT as is commonly performed by many of our customers as well. This particular antibody has only been tested on paraffin embedded samples and has not yet been tested on frozen, so it cannot be guaranteed, but will most likely work. For the antigen retrieval we recommend our standard heat mediated citrate buffer at pH 6.0.

Secondary Antibodies

 

Isotype Controls

Other Available Formats

DyLight 488 Labeled NB110-58345G
DyLight 550 Labeled NB110-58345R
DyLight 650 Labeled NB110-58345C
HRP Labeled NB110-58345H

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Bioinformatics Tool for CDR2 Antibody (NB110-58345B)

Discover related pathways, diseases and genes to CDR2 Antibody (NB110-58345B). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Research Areas for CDR2 Antibody (NB110-58345B)

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Blogs on CDR2.

Cerebellar Degeneration-Related Protein 2 (CDR2): Cell-Cycle Regulated Tumor Antigen
CDR2 is a tumor antigen expressed in a high percentage of breast and ovarian tumors and is the target of a naturally occurring tumor immune response in patients with paraneoplastic cerebellar degeneration. CDR2 has also been shown to be a cell cycle r...  Read full blog post.

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Bioinformatics

Gene Symbol CDR2