Western Blot: CDR2 Antibody [NB110-58345] - Cdr2 expressed during mitosis, ubiquitinated and degraded during mitotic exit. Upper left, flow cytometry of G1/S- and G2/M-arrested HEK293s. Upper right, western blots of ...read more
Immunohistochemistry: CDR2 Antibody [NB110-58345] - Purkinje neurons of the cerebellum.
Flow Cytometry: CDR2 Antibody [NB110-58345] - Analysis using the DyLight 488 conjugate of NB110-58345. Thymus epithelial cells CDR2. Image from verified customer review.
Western Blot: CDR2 Antibody [NB110-58345] - Analysis of CDR2 antibody on HeLa whole cell.
This CDR2 antibody is useful for Immunohistochemistry paraffin embedded sections, and Western blot analysis where a band is seen at ~51 kDa. Immunocytochemistry/Immunofluorescence was reported in scientific literature. Flow data from customer review. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
51 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
CDR2 (cerebellar degeneration-related protein 2; encoded by gene CDR2 or PCD17) was initially discovered in a search for novel PHD1-interacting proteins, and comprehensive analysis of human cancers revealed very strong CDR2 expression in papillary subtype of renal cell carcinoma, wherein high CDR2 protein levels correlated with strongly attenuated expression of HIF target genes. Accordingly, CDR2 overexpression in cancer cell lines reduced HIF-dependent transcriptional regulation, possibly because of both regulation of PHD1 protein expression and suppression of transactivation potential of HIF-1alpha. CDR2 through its leucine zipper motif has been shown to interact with CMYC, cell cycle-related proteins and with protein kinases suggesting its important role in biological functions including signal transduction, gene transcription and cellular proliferation.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
FAQs for CDR2 Antibody (NB110-58345). (Showing 1 - 1 of 1 FAQ).
I'm looking for an antibody against human CDR2 to recognize thymic epithelial cells. You have several anti CDR2 antibodies. Are they against a thymic epithelial antigen or against the cerebellar degeneration-related protein 2, 62kDa?
Yes, the specific antibody you have inquired about is against cerebellar degeneration-related protein 2, 62 kDa. Moreover, all of our CDR2 primaries are against the same target.
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Bio-Techne appreciates the critical role that you and our products and services play in research efforts to further scientific innovation and discovery. We are continually assessing our manufacturing and supplier capabilities during the COVID-19 situation and are implementing precautionary measures to ensure uninterrupted supply of products and services. Currently, and as we abide by local shelter in place orders across the world, we are fully operational and do not anticipate any material supply disruptions across our Bio-Techne brands and product lines. As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally.