CDR2 Antibody

Images

 
Western Blot: CDR2 Antibody [NB110-58345] - Cdr2 expressed during mitosis, ubiquitinated and degraded during mitotic exit. Upper left, flow cytometry of G1/S- and G2/M-arrested HEK293s. Upper right, western blots of ...read more
Immunohistochemistry: CDR2 Antibody [NB110-58345] - Purkinje neurons of the cerebellum.
Flow Cytometry: CDR2 Antibody [NB110-58345] - Analysis using the DyLight 488 conjugate of NB110-58345. Thymus epithelial cells CDR2. Image from verified customer review.
Western Blot: CDR2 Antibody [NB110-58345] - Analysis of CDR2 antibody on HeLa whole cell.

Product Details

Summary
Reactivity Hu, Mu, Bv, PmSpecies Glossary
Applications WB, Flow, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

CDR2 Antibody Summary

Immunogen
A synthetic peptide made to a C-terminal region of human CDR2 [Swiss-Prot# Q01850]
Localization
Cytoplasmic and Nuclear
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CDR2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 2 ug/ml
  • Flow Cytometry
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry 5-10 ug/ml
  • Immunohistochemistry-Paraffin 5-10 ug/ml
Application Notes
This CDR2 antibody is useful for Immunohistochemistry paraffin embedded sections, and Western blot analysis where a band is seen at ~51 kDa. Immunocytochemistry/Immunofluorescence was reported in scientific literature. Flow data from customer review. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
51 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Control
HeLa Whole Cell Lysate
CDR2 Overexpression Lysate
Control Peptide
CDR2 Peptide (NB110-58345PEP)
Publications
Read Publication using
NB110-58345 in the following applications:

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: rat (85%).

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Tris-Citrate/Phosphate (pH 7.0 - 8.0)
Preservative
0.1% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CDR2 Antibody

  • CDR62
  • cerebellar degeneration-related protein (62kD)
  • cerebellar degeneration-related protein 2
  • cerebellar degeneration-related protein 2, 62kDa
  • Major Yo paraneoplastic antigen
  • Paraneoplastic cerebellar degeneration-associated antigen
  • PCD17
  • Yo paraneoplastic antigen
  • Yo

Background

CDR2 (cerebellar degeneration-related protein 2; encoded by gene CDR2 or PCD17) was initially discovered in a search for novel PHD1-interacting proteins, and comprehensive analysis of human cancers revealed very strong CDR2 expression in papillary subtype of renal cell carcinoma, wherein high CDR2 protein levels correlated with strongly attenuated expression of HIF target genes. Accordingly, CDR2 overexpression in cancer cell lines reduced HIF-dependent transcriptional regulation, possibly because of both regulation of PHD1 protein expression and suppression of transactivation potential of HIF-1alpha. CDR2 through its leucine zipper motif has been shown to interact with CMYC, cell cycle-related proteins and with protein kinases suggesting its important role in biological functions including signal transduction, gene transcription and cellular proliferation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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NB110-58345
Species: Hu, Mu, Bv, Pm
Applications: WB, Flow, ICC/IF, IHC, IHC-P

Publications for CDR2 Antibody (NB110-58345)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: ICC/IF, WB.


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ICC/IF
(1)
WB
(1)
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Product General Protocols

View specific protocols for CDR2 Antibody (NB110-58345): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for CDR2 Antibody (NB110-58345). (Showing 1 - 1 of 1 FAQ).

  1. I'm looking for an antibody against human CDR2 to recognize thymic epithelial cells. You have several anti CDR2 antibodies. Are they against a thymic epithelial antigen or against the cerebellar degeneration-related protein 2, 62kDa?
    • Yes, the specific antibody you have inquired about is against cerebellar degeneration-related protein 2, 62 kDa. Moreover, all of our CDR2 primaries are against the same target.

Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NB110-58345AF350
Alexa Fluor 405 NB110-58345AF405
Alexa Fluor 488 NB110-58345AF488
Alexa Fluor 532 NB110-58345AF532
Alexa Fluor 594 NB110-58345AF594
Alexa Fluor 647 NB110-58345AF647
Alexa Fluor 700 NB110-58345AF700
Alexa Fluor 750 NB110-58345AF750
Biotin NB110-58345B
DyLight 350 NB110-58345UV
DyLight 405 NB110-58345V
DyLight 488 NB110-58345G
DyLight 550 NB110-58345R
DyLight 594 NB110-58345DL594
DyLight 650 NB110-58345C
DyLight 680 NB110-58345FR
DyLight 755 NB110-58345IR
FITC NB110-58345F
HRP NB110-58345H
Janelia Fluor 549 NB110-58345JF549
Janelia Fluor 646 NB110-58345JF646

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Research Areas for CDR2 Antibody (NB110-58345)

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Blogs on CDR2.

Cerebellar Degeneration-Related Protein 2 (CDR2): Cell-Cycle Regulated Tumor Antigen
CDR2 is a tumor antigen expressed in a high percentage of breast and ovarian tumors and is the target of a naturally occurring tumor immune response in patients with paraneoplastic cerebellar degeneration. CDR2 has also been shown to be a cell cycle r...  Read full blog post.

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Bioinformatics

Gene Symbol CDR2
Entrez
Uniprot