CDNF Antibody - BSA Free

Western Blot: CDNF Antibody [NBP1-76835] - A-20 cell lysate in (A) the absence and (B) the presence of blocking peptide with CDNF antibody at 1 ug/ml.

Immunohistochemistry: CDNF Antibody - BSA Free [NBP1-76835] - Immunohistochemistry of CDNF in human brain tissue with CDNF antibody at 5 ug/mL.

Immunocytochemistry/ Immunofluorescence: CDNF Antibody - BSA Free [NBP1-76835] - Immunofluorescence of CDNF in Human Brain cells with CDNF antibody at 20 ug/mL.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

CDNF Antibody - BSA Free Summary

• Immunogen: Antibody was raised against a 12 amino acid synthetic peptide from near the amino terminus of human CDNF. The immunogen is located within the first 50 amino acids of CDNF. Amino Acid Squence: QGQEAGGRPGAD
• Specificity: This antibody does not cross-react with MANF.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CDNF
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 20 ug/ml
  • Immunohistochemistry 5 ug/ml
  • Immunohistochemistry-Paraffin 5 ug/ml
  • Western Blot 1 ug/ml
• Control Peptide:

  CDNF Peptide (NBP1-76835PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for CDNF Antibody - BSA Free

• arginine-rich, mutated in early stage tumors-like 1
• ARMETL1
• ARMET-like protein 1
• CDNF
• cerebral dopamine neurotrophic factor
• Conserved dopamine neurotrophic factor

Background

The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and highly homologous to the mesencephalic-astrocyte-derived neuro-trophic factor. Somewhat surprisingly, CDCF is expressed at higher levels in tissues such as heart, skeletal muscle and testes than in brain. Similar to the glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent the 6-hydroxylamine (6-OHDA)-induced degeneration of dopaminergic neurons in a rat model of Parkinson's disease. Furthermore, CDNF was able to restore the dopaminergic function and prevent the degeneration of dopaminergic neurons in the substantia nigra, suggesting that CDNF might be suitable for the treatment of Parkinson's disease. At least two isoforms of CDNF are known to exist. This antibody does not cross-react with MANF.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CDNF
• Uniprot:
  • Q49AH0(Human)