CDNF Antibody - BSA Free

Western Blot: CDNF Antibody [NBP1-76834] - Mouse brain tissue lysate with CDNF antibody at (A) 2 and (B) 4 ug/ml.

Immunocytochemistry/Immunofluorescence: CDNF Antibody - BSA Free [NBP1-76834] - CDNF Antibody [NBP1-76834] - Staining of CDNF in mouse brain tissue with at 20 ug/mL.

Immunohistochemistry-Paraffin: CDNF Antibody [NBP1-76834] - Staining of CDNF in mouse brain tissue with at 5 ug/mL.

Immunocytochemistry/Immunofluorescence: CDNF Antibody - BSA Free [NBP1-76834] - CDNF Antibody [NBP1-76834] - Human Brain cell antibody at 20 ug/mL.

Immunohistochemistry-Paraffin: CDNF Antibody [NBP1-76834] - Human brain tissue with CDNF antibody at 2.5 ug/ml.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, ICC/IF, IHC, IHC-P
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

CDNF Antibody - BSA Free Summary

• Immunogen: Antibody was raised against a 9 amino acid synthetic peptide from near the carboxy terminus of human CDNF. The immunogen is located within the last 50 amino acids of CDNF. Amino Acid Squence: YAATHPKTE
• Specificity: This antibody does not cross-react with MANF.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CDNF
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 20 ug/ml
  • Immunohistochemistry 2.5 ug/ml
  • Immunohistochemistry-Paraffin 2.5 ug/ml
  • Western Blot 2-4 ug/ml
• Control Peptide:

  CDNF Peptide (NBP1-76834PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for CDNF Antibody - BSA Free

• arginine-rich, mutated in early stage tumors-like 1
• ARMETL1
• ARMET-like protein 1
• CDNF
• cerebral dopamine neurotrophic factor
• Conserved dopamine neurotrophic factor

Background

The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and highly homologous to the mesencephalic-astrocyte-derived neuro-trophic factor. Somewhat surprisingly, CDCF is expressed at higher levels in tissues such as heart, skeletal muscle and testes than in brain. Similar to the glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent the 6-hydroxylamine (6-OHDA)-induced degeneration of dopaminergic neurons in a rat model of Parkinson's disease. Furthermore, CDNF was able to restore the dopaminergic function and prevent the degeneration of dopaminergic neurons in the substantia nigra, suggesting that CDNF might be suitable for the treatment of Parkinson's disease. At least two isoforms of CDNF are known to exist. This antibody does not cross-react with MANF.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CDNF Antibody (NBP1-76834)(1)

Publication using NBP1-76834

• Lin Y, Tang L, Huang P et al. Mechanisms of Cong Rong Shu Jing Compound Effects on Endoplasmic Reticulum Stress in a Rat Model of Parkinson’s Disease Evidence-Based Complementary and Alternative Medicine 2020-05-14 [PMID: 32508943] (WB, Rat)

Bioinformatics

• Gene Symbol: CDNF
• Uniprot:
  • Q49AH0(Human)