CDC42 Antibody (3193C) [Alexa Fluor® 700]

• Reactivity: Hu
• Clone: 3193C
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Alexa Fluor 700

CDC42 Antibody (3193C) [Alexa Fluor® 700] Summary

• Immunogen: Synthetic Peptide
• Specificity: Detects a synthetic peptide specific for human CDC32 around amino acid 140 in Direct ELISA.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CDC42 Antibody (3193C) [Alexa Fluor® 700]

• CDC42
• CDC42Hs
• cell division control protein 42 homolog
• cell division cycle 42 (GTP binding protein, 25kDa)
• cell division cycle 42 (GTP-binding protein, 25kD)
• dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD))
• dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD))
• G25K GTP-binding protein
• G25K
• growth-regulating protein
• GTP-binding protein, 25kD
• small GTP binding protein CDC42

Background

Cell division control protein 42 (CDC42) is a small Rho GTPase with a molecular weight of approximately 21 kDa. CDC42 is a highly conserved protein that plays an integral role in regulating multiple cellular processes, including cytoskeletal organization, cell polarity, vesicle trafficking, and signal transduction. A key regulator of the actin cytoskeleton, CDC42 is critical for the formation of filopodia, which are dynamic, actin-rich cell protrusions involved in sensing the extracellular environment. CDC42 is ubiquitously expressed across eukaryotic cells and contributes to essential biological functions such as cell migration, adhesion, and mitotic spindle orientation. Dysregulation of CDC42 activity is implicated in a variety of pathological conditions, including cancer metastasis, where it drives tumor cell migration and invasion, as well as immune disorders resulting from aberrant cell polarization and trafficking. Mutations in genes regulating CDC42 and its activity are associated with developmental disorders, such as Takenouchi-Kosaki syndrome. Given its central role in cellular signaling and cytoskeletal dynamics, CDC42 is a key player in numerous physiological and pathological contexts, making it a valuable biomarker and therapeutic target.

1. Ridley AJ. Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking. Trends Cell Biol. 2006 Oct;16(10):522-9. doi: 10.1016/j.tcb.2006.08.006. Epub 2006 Sep 1. PMID: 16949823.
2. Johnson DI. Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity. Microbiol Mol Biol Rev. 1999 Mar;63(1):54-105. doi: 10.1128/MMBR.63.1.54-105.1999. PMID: 10066831; PMCID: PMC98957.
3. Jahid S, Ortega JA, Vuong LM, Acquistapace IM, Hachey SJ, Flesher JL, La Serra MA, Brindani N, La Sala G, Manigrasso J, Arencibia JM, Bertozzi SM, Summa M, Bertorelli R, Armirotti A, Jin R, Liu Z, Chen CF, Edwards R, Hughes CCW, De Vivo M, Ganesan AK. Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer. Cell Rep. 2022 Apr 5;39(1):110641. doi: 10.1016/j.celrep.2022.110641. Erratum in: Cell Rep. 2022 Apr 26;39(4):110760. doi: 10.1016/j.celrep.2022.110760. PMID: 35385746; PMCID: PMC9127750.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.