Flow Cytometry: CD69 Antibody (H1.2F3) [NBP1-28011] - PMA and Ionomycin stimulated BALB/c mouse splenocytes were stained with Hamster Anti-Mouse CD69-PACBLU.
Flow Cytometry: CD69 Antibody (H1.2F3) [NBP1-28011] - Analysis using the FITC conjugate of NBP1-28011. Less than or equal to 1 ug/10^6 Fresh BALB/c spleen cells were activated by incubation for 20 hours with PMA + ...read more
CD69 antigen (p60, early T-cell activation antigen)
CLEC2CC-type lectin domain family 2 member C
C-type lectin domain family 2, member C
early activation antigen CD69
early lymphocyte activation antigen
Early T-cell activation antigen p60
Leukocyte surface antigen Leu-23
CD69, also known as very early activation (VEA) antigen, is a disulfide-linked transmembrane homodimer whose differentially glycosylated subunits range from 35-39 kDa. (1,2) It is a C-type lectin, most closely related to the NKR-P1 and Ly-49 NK cell-activation molecules. (3) CD69 is widely expressed on hematopoietic cells, including lymphocytes, neutrophils and eosinophils. (1-4) Although not detectable on resting lymphocytes, its expression is rapidly (within 2 hours) upregulated upon activation of T, B and NK cells, and neutrophils. (4) Constitutive expression of CD69 on subsets of thymocytes suggests that it may be involved in regulation of developmental events in addition to its role in activation of a variety of hematopoietic cells. (4,5) MAb H1.2F3 augments PMA-induced T-cell proliferation,1,6 and induces redirected lysis of Fc receptor-bearing target cells by NK cells. (7)
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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