CD69 Antibody (H1.2F3) Summary
Mouse dendritic epidermal cell line Y245
Mouse CD69/Very Early Activation Antigen (VEA), Mr 85 kDa (unreduced)
Protein A or G purified
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- Flow Cytometry 1:10-1:1000
- Immunohistochemistry 1:10-1:500
- Immunohistochemistry-Frozen 1:10-1:500
- Immunoprecipitation 1:10-1:500
- In vitro assay
Flow Cytometry, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen and In vitro assay
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
0.1M BBS (pH 8.2)
Protein A or G purified
Alternate Names for CD69 Antibody (H1.2F3)
- activation inducer molecule (AIM/CD69)
- Activation inducer molecule
- CD69 antigen (p60, early T-cell activation antigen)
- CD69 antigen
- CD69 molecule
- CLEC2CC-type lectin domain family 2 member C
- C-type lectin domain family 2, member C
- early activation antigen CD69
- early lymphocyte activation antigen
- Early T-cell activation antigen p60
- Leukocyte surface antigen Leu-23
CD69, also known as very early activation (VEA) antigen, is a disulfide-linked transmembrane homodimer whose differentially glycosylated subunits range from 35-39 kDa. (1,2) It is a C-type lectin, most closely related to the NKR-P1 and Ly-49 NK cell-activation molecules. (3) CD69 is widely expressed on hematopoietic cells, including lymphocytes, neutrophils and eosinophils. (1-4) Although not detectable on resting lymphocytes, its expression is rapidly (within 2 hours) upregulated upon activation of T, B and NK cells, and neutrophils. (4) Constitutive expression of CD69 on subsets of thymocytes suggests that it may be involved in regulation of developmental events in addition to its role in activation of a variety of hematopoietic cells. (4,5) MAb H1.2F3 augments PMA-induced T-cell proliferation,1,6 and induces redirected lysis of Fc receptor-bearing target cells by NK cells. (7)
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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