CD69 Products

Description

CD69, also known as very early activation (VEA) antigen, is a disulfide-linked transmembrane homodimer whose differentially glycosylated subunits range from 35-39 kDa. (1,2) It is a C-type lectin, most closely related to the NKR-P1 and Ly-49 NK cell-activation molecules. (3) CD69 is widely expressed on hematopoietic cells, including lymphocytes, neutrophils and eosinophils. (1-4) Although not detectable on resting lymphocytes, its expression is rapidly (within 2 hours) upregulated upon activation of T, B and NK cells, and neutrophils. (4) Constitutive expression of CD69 on subsets of thymocytes suggests that it may be involved in regulation of developmental events in addition to its role in activation of a variety of hematopoietic cells. (4,5) MAb H1.2F3 augments PMA-induced T-cell proliferation,1,6 and induces redirected lysis of Fc receptor-bearing target cells by NK cells. (7)

Bioinformatics

Entrez	12515 Mouse 969 Human
Uniprot	AAH07037 Human NM_001781 Human NP_001772 Human NP_001772.1 Human Q07108 Human
Product By Gene ID	969
Alternate Names	activation inducer molecule (AIM/CD69) Activation inducer molecule AIM BL-AC/P26 CD69 antigen (p60, early T-cell activation antigen) CD69 antigen CD69 molecule CLEC2CC-type lectin domain family 2 member C C-type lectin domain family 2, member C EA1 early activation antigen CD69 early lymphocyte activation antigen Early T-cell activation antigen p60 GP32/28 Leukocyte surface antigen Leu-23 MLR-3