CD46 Antibody (122.2)

Images

 
Flow Cytometry: CD46 Antibody (122.2) [NBP2-25222] - Using the PE direct conjugate A surface stain was performed on hPBMCs with CD46 antibody (122.2) NBP2-33159PE (blue) and a matched isotype control (orange). Cells ...read more
Flow Cytometry: CD46 Antibody (122.2) [NBP2-25222] - Surface staining of human PBMCs using CD46 antibody at 1 ug/10^6 cells. this antibody and FACS surface staining kit this antibody were used for this test.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, IF
Clone
122.2
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

CD46 Antibody (122.2) Summary

Immunogen
A recombinant protein fragment specific for human CD46 was used as the immunogen.
Localization
Cell surface
Marker
T-Cell Marker
Specificity
CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
CD46
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 0.5-1ug/million cells in 0.1ml
  • Immunofluorescence 0.5-1ug/ml
Application Notes
Human Chromosome Location: 1q32.2
Mol. Weight of Antigen: 56-66kDa

Packaging, Storage & Formulations

Storage
Store at 4C.
Buffer
PBS with 0.05% BSA.
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Alternate Names for CD46 Antibody (122.2)

  • AHUS2
  • CD46 antigen
  • CD46 molecule, complement regulatory protein
  • CD46
  • MCP
  • membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)
  • MIC10
  • TLXcomplement regulatory protein
  • trophoblast leucocyte common antigen
  • Trophoblast leukocyte common antigen
  • trophoblast-lymphocyte cross-reactive antigen

Background

CD46 acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CD46
Entrez
Uniprot

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