CD46 Antibody (122.2) [FITC]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA, Flow, ICC/IF, IHC-Fr
Clone
122.2
Clonality
Monoclonal
Host
Mouse
Conjugate
FITC

CD46 Antibody (122.2) [FITC] Summary

Immunogen
A recombinant protein fragment specific for human CD46 was used as the immunogen.
Localization
Cell surface
Marker
T-Cell Marker
Specificity
CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
CD46
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA
  • Flow Cytometry
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry-Frozen
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for CD46 Antibody (122.2) [FITC]

  • AHUS2
  • CD46 antigen
  • CD46 molecule, complement regulatory protein
  • CD46
  • MCP
  • membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)
  • MIC10
  • TLXcomplement regulatory protein
  • trophoblast leucocyte common antigen
  • Trophoblast leukocyte common antigen
  • trophoblast-lymphocyte cross-reactive antigen

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Bioinformatics

Gene Symbol CD46