CD42b/GPIb alpha Antibody (HIP1) [DyLight 488]

• Reactivity: Hu, Mu, Pm
• Applications: Flow, IHC, CyTOF-ready
• Clone: HIP1
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 488

CD42b/GPIb alpha Antibody (HIP1) [DyLight 488] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Additional Information: Clone HIP1 was used by HLDA to establish CD designation.
• Immunogen: Peripheral blood mononuclear cells of a patient suffering with CLL.
• Specificity: The antibody HIP1 reacts with CD42b (GPIb alpha), a 135-145 kDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are composed in a disulfide linked heterodimer (CD42b/c; 160 kDa); CD42b/c forms a noncovalent complex with CD42a and CD42d. HLDA IV; WS Code P 40
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: GP1BA
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
• Application Notes: Recommended applications are based on validated applications from the unconjugated base product NB500-511. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 31467123).

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for CD42b/GPIb alpha Antibody (HIP1) [DyLight 488]

• Antigen CD42b-alpha
• BP1BA
• BSS
• CD42b antigen
• CD42b
• CD42b-alpha
• glycoprotein Ib (platelet), alpha polypeptide
• Glycoprotein Ibalpha
• GP1B
• GP1BA
• GPIb alpha
• GP-Ib alpha
• GPIbA
• GPIb-alpha
• MGC34595
• platelet glycoprotein Ib alpha chain
• platelet membrane glycoprotein 1b-alpha subunit

Background

CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. Its expression and activation seems to be regulated by VEGF and PDGF.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GP1BA