CD38 Antibody (Hu208) [Alexa Fluor™ Plus 594]

• Reactivity: Hu
• Clone: Hu208
• Clonality: Monoclonal
• Host: Human
• Conjugate: Alexa Fluor Plus 594

CD38 Antibody (Hu208) [Alexa Fluor™ Plus 594] Summary

• Specificity: Detects human CD38 in direct ELISAs.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Human

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CD38 Antibody (Hu208) [Alexa Fluor™ Plus 594]

• 2'-phospho-ADP-ribosyl cyclase
• 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20)
• 2'-phospho-cyclic-ADP-ribose transferase
• ADPRC 1
• ADPRC1
• ADP-ribosyl cyclase 1
• ADP-ribosyl Cyclase
• ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
• ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
• cADPr hydrolase 1
• CD_antigen: CD38
• CD38 antigen (p45)
• CD38 antigen
• CD38 molecule
• CD38
• cluster of differentiation 38
• Cyclic ADP-ribose hydrolase 1
• Cyclic ADP-ribose Hydrolase
• EC 2.4.99.20
• EC 3.2.2.6
• EC:3.2.2.6
• NAD(+) nucleosidase
• T10

Background

CD38, also known as ADP-ribosyl cyclase, is a Type II integral membrane protein. The enzyme is able to transform NAD(P)⁺ into three different products with calcium mobilizing ability, cyclic ADP-ribose, NAADP⁺, and ADP-ribose (1). CD38 is expressed in B and T lymphocytes, osteoclasts, and in cardiac, pancreatic, liver and kidney cells (2, 3). Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in many types of cells, including neutrophils and pancreatic beta  cells (4, 5). Bio-Techne's Daratumumab biosimilar is produced using the full-length amino acid sequence which is identical to that of the original therapeutic antibody.

1. Schuber, F. and F.E. Lund (2004) Curr. Mol. Med. 4:249.
2. Jackson, D.G. and J.I. Bell (1990) J. Immunol. 144:2811.
3. Sun, L. et al. (1999) J. Cell Biol. 146:1161.
4. Partida-Sanchez, S. et al. (2001) Nature Med. 7:1209.
5. Kato, I. et al. (1995) J. Biol. Chem. 270:30045.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

FAQs for CD38 Antibody (FAB11493AFP594). (Showing 1 - 1 of 1 FAQ).

1. Which is your best antibody anti-human CD38 for IHC-P?
   • We do have a number of CD38 antibodies validated in IHC-P, please use the filters on the left side of the search page to help find the product that mostly suits to your experimental design.