CD3 epsilon Antibody (C363.29B (YCD3-1)) [Biotin] Summary
The immunogen is a peptide made to the amino acid region CD3 epsilon
Mouse CD3 epsilon (Mr 25 kD)
Protein A or G purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
Biotin (A=N/A, E=N/A)
0.05% Sodium Azide
Protein A or G purified
Protect conjugated forms from light.
Alternate Names for CD3 epsilon Antibody (C363.29B (YCD3-1)) [Biotin]
- CD3e antigen
- CD3e antigen, epsilon polypeptide (TiT3 complex)
- CD3e molecule, epsilon (CD3-TCR complex)
- T-cell antigen receptor complex, epsilon subunit of T3
- T-cell surface antigen T3/Leu-4 epsilon chain
- T-cell surface glycoprotein CD3 epsilon chain
T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits: CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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Publications for CD3 epsilon Antibody (NBP1-26687)(5)
Showing Publications 1 - 5
|Publications using NBP1-26687
|WhitelJL, Nicholls SM, Shimeld C et al. Immunohistochemical detection of T-cell subsets and other leukocytes in paraffin-embedded rat and mouse tissues with monoclonal antibodies. J Histochem Cytochem. 1995 Mar. [PMID:7868861]
|Portoles P, Rojo J, Golby A et al. Monoclonal antibodies to murine CD3 epsilon define distinct epitopes, one of which may interact with CD4 during T cell activation. J Immunol. 1989 Jun. [PMID:2470817]
|Dianzani U, Luqman M, Rojo J et al. Molecular associations on the T cell surface correlate with immunological memory. Eur J Immunol. 1990 Oct. [PMID:1978709]
|Ernst DN, Hobbs MV, Torbett BE et al. Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice. J Immunol. 1990 Sep. [PMID:1974562]
|Luqman M, Greenbaum L, Lu D et al. Differential effect of interleukin 1 on naive and memory CD4+ T cells. Eur J Immunol. 1992 Jan. [PMID:1346115]
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Product General Protocols
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FAQs for CD3 epsilon Antibody (NBP1-26687). (Showing 1 - 2 of 2 FAQs).
Which antigen retrieval or protease pretreatment is appropriate for NBP1-26687 when it was used for Formalin-Fixed, parraffin embedded (FFPE) bone marrow tissue sections?
- Our lab routinely follows a citrate buffer method. Please see our antigen retrieval protocol.
What is the dilution for Immunohistochemistry-Paraffin with NBP1-26687?
- I would recommend 1:100-1:200 as a starting dilution for IHC-P, and then you may need to optimize from there depending on your experimental conditions.
Other Available Formats
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