Flow, IP, CyTOF-reported, ICC, TstimHost:
Flow, IHC, IHC-Fr, IHC-P, In vitro, IP, BAHost:
Flow, IP, Cell Depl, CyTOF-reported, TstimHost:
Applications: WB, ELISA, PA
Applications: RNAi, RNAi SP
CD3 epsilon is a subunit of CD3. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits: CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.
|Product By Gene ID
- CD3e antigen
- T-cell surface glycoprotein CD3 epsilon chain
- T-cell surface antigen T3/Leu-4 epsilon chain
- T-cell antigen receptor complex, epsilon subunit of T3
- CD3e antigen, epsilon polypeptide (TiT3 complex)
- CD3e molecule, epsilon (CD3-TCR complex)
Bioinformatics Tool for CD3 epsilon
Discover related pathways, diseases and genes to CD3 epsilon. Need help? Read the Bioinformatics Tool Guide
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