CD21 Antibody (B-E5) - Azide and BSA Free

Flow Cytometry: CD21 Antibody (B-E5) [NBP3-14587] - A typical staining pattern with the B-E5 monoclonal antibody of lymphocytes.

• Reactivity: Hu
• Applications: Flow, Func
• Clone: B-E5
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free
• Concentration: 1 mg/ml

CD21 Antibody (B-E5) - Azide and BSA Free Summary

• Description: Stable at 4C for 12 months.
  
  Hybridoma: Myeloma X63/AG.8653 x Balb/c spleen cells
• Immunogen: Daudi cell line
• Isotype: IgG2a Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: CR2
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Functional
• Application Notes: Biological Activity: Induces human B-cell proliferation and competes with EBV for CD21 binding.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS. Sterile-filtered through 0.22 um.
• Preservative: No Preservative
• Concentration: 1 mg/ml
• Purity: Affinity purified

Alternate Names for CD21 Antibody (B-E5) - Azide and BSA Free

• C3DR
• C3DRSLEB9
• CD21 antigen
• CD21
• Complement C3d receptor
• complement component (3d/Epstein Barr virus) receptor 2
• complement receptor type 2
• CR2
• EBV receptor
• Epstein-Barr virus receptor

Background

CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CR2