CD21 Antibody (4C5)

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Product Details

Summary
Reactivity RtSpecies Glossary
Applications Flow, ICC/IF, IHC, IHC-Fr, CyTOF-ready
Clone
4C5
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

CD21 Antibody (4C5) Summary

Immunogen
The antibody reacts with the CD21 antigen.
Marker
Histiocytic Marker
Specificity
This antibody reacts with the CD21 (140kD) molecule, expressed (moderate) on mature B-cells and (at high density) on follicular dendritic cells (FDC).
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
CR2
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry 1:50
  • Immunocytochemistry/Immunofluorescence 1:20
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:20-1:50
  • CyTOF-ready
Application Notes
4C5 shows moderate labeling of mature B-cells and strong labeling of FDC's on acetone-fixed cryostat sections, air-dried and acetone-fixed cells and immunofluorescence and immuno-peroxidase tests. Immunohistochemistry: use approx. 1:20-1:50 dil.

Reactivity Notes

Rat

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
No buffer
Preservative
0.1% Sodium Azide
Purity
Protein A or G purified

Notes

Please note: the product size for this product was decreased from 5ml to 1ml on October 12, 2010.

Alternate Names for CD21 Antibody (4C5)

  • C3DR
  • C3DRSLEB9
  • CD21 antigen
  • CD21
  • Complement C3d receptor
  • complement component (3d/Epstein Barr virus) receptor 2
  • complement receptor type 2
  • CR2
  • EBV receptor
  • Epstein-Barr virus receptor

Background

CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Blogs on CD21.

CD19: An Undoubted Biomarker for B Cells
CD19 is a cell surface protein member of the large immunoglobulin superfamily that complexes with CD21, CD81, and CD225 in the membrane of mature B-cells. A major function of CD19 is to assemble with the antigen receptor of B-lymphocytes to decrease t...  Read full blog post.

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Bioinformatics

Gene Symbol CR2
Entrez