Immunohistochemistry-Paraffin: MS4A1/CD20 Antibody (E17-P) [NBP1-30144] - CD20 expression in b-lymphocytes of the palatine tonsil. Formalin fixed, paraffin embedded human tissues (4 um sections) stained with anti- CD20 ...read more
Immunohistochemistry-Paraffin: MS4A1/CD20 Antibody (E17-P) [NBP1-30144] - Chronic lymphocytic leukaemia cells in the bone marrow biopsy, showing CD20 expression.Formalin fixed, paraffin embedded human tissues (4 um ...read more
This antibody is immunoaffinity purified with immunogenic peptide as a ligand.
Alternate Names for CD20 Antibody (E17-P)
B-lymphocyte antigen CD20
B-lymphocyte cell-surface antigen B1
B-lymphocyte surface antigen B1
Leukocyte surface antigen Leu-16
Membrane-spanning 4-domains subfamily A member 1
membrane-spanning 4-domains, subfamily A, member 1
CD20 is a cell surface 33-37 (depending on the degree of phosphorylation) kDa non-glycosylated surface phosphoprotein expressed on mature and most malignant B cells, but not stem cells or plasma cells (low number of the CD20 has been also detected on a subpopulation of T lymphocytes and it can be expressed on follicular dendritic cells). Its expression on B cells is synchronous with the expression of surface IgM. CD20 regulates transmembrane calcium conductance (probably functioning as a component of store-operated calcium channel), cell cycle progression and B-cell proliferation. It is associated with lipid rafts, but the intensity of this association depends on extracellular triggering, employing CD20 conformational change and/or BCR (B cell antigen receptor) aggregation. After the receptor ligation, BCR and CD20 colocalize and then rapidly dissociate before BCR endocytosis, whereas CD20 remains at the cell surface. CD20 serves as a useful target for antibody-mediated therapeutic depletion of B cells, as it is expressed at high levels on most B-cell malignancies, but does not become internalized or shed from the plasma membrane following mAb treatment.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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