CCRL2/CRAM-A/B Antibody (152254) [Allophycocyanin]

• Applications: Flow
• Clone: 152254
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Allophycocyanin

CCRL2/CRAM-A/B Antibody (152254) [Allophycocyanin] Summary

• Immunogen: NS0 mouse myeloma cell line transfected with human CRAM-A
  Met1-Val356 (Val180Met)
  Accession # NP_001124382
• Specificity: Detects human CCRL2/CRAM‑A/B. Stains human CCRL2-transfected cells but not irrelevant transfectants. Detects both the CRAM-A and CRAM-B isoforms.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: CCRL2
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

CCRL2, also known as CCR11, CRAM-A, CRAM-B, CKRX, and HCR, is a seven-transmembrane G-protein linked receptor that shares homology with other human chemokine receptors. The isoforms CRAM-A and CRAM-B differ at their N-termini by the insertion of an additional 12 amino acids in CRAM-A. CCRL2/CRAM‑A/B is expressed at varying levels on a variety of peripheral blood cells including monocytes, neutrophils, B cells, and T cells (1, 2). CCL19 has been identified as a ligand for CRAM-B (4). Human and mouse CRAM share approximately 47% amino acid sequence identity.

1. Fan, P. et al. (1998) Biochem. Biophys. Res. Commun. 243:264.
2. Migeotte, I. et al. (2002) Eur. J. Immunol. 32:494.
3. Hartmann, T.N. et al. (2008) Immunology 125:252.
4. Leick, M. et al. (2010) Immunology 129:536.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CCRL2