CCR5 Antibody

Immunohistochemistry-Paraffin: CCR5 Antibody [NB100-714] - Paraffin sections of human spleen tissue.

• Reactivity: Hu, RM, V-Vi
• Applications: WB, ELISA, IHC
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated

CCR5 Antibody Summary

• Description: Novus Biologicals Goat CCR5 Antibody (NB100-714) is a polyclonal antibody validated for use in IHC, WB and ELISA. Anti-CCR5 Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Synthetic peptide 3YQVSSPIYDINYYTSEPCQKINVKQIAA30 corresponding to the N-terminal sequence of human CCR5
• Localization: Plasma membrane
• Specificity: This binds to CCR 5 receptors on human peripheral blood leukocytes as determined by immunohistochemistry.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: CCR5
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:25000
  • Immunohistochemistry 1:150
  • Immunohistochemistry-Paraffin 1:150
  • Western Blot 1:500

Reactivity Notes

Virus reactivity reported in scientific literature (PMID: 25067937).

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: 10mM KHPO4 and 0.14M NaCl, BSA @ 1mg/ml
• Preservative: 0.1% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for CCR5 Antibody

• C-C CKR-5
• C-C motif chemokine receptor 5 A159A
• CCCKR5
• CC-CKR-5FLJ78003
• CCR5
• CCR-5
• CD195 antigen
• CD195
• chemokine (C-C motif) receptor 5
• chemokine receptor CCR5
• chemr13
• CKR5
• CKR-5
• HIV-1 fusion coreceptor
• IDDM22CMKBR5C-C chemokine receptor type 5

Background

Receptors for the C-C chemokine family include CCR 1, CCR 2A, CCR 3, CCR 4, CCR 5 and the Duffy blood group antigen. The C-C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation. The HIV receptor is composed of two molecules, the CD4 binding receptor and a co-receptor. The chemokine receptor CCR 5 is one of the co-receptors used by primary isolates of HIV-1. Extracellular domains of CCR 5 are important for HIV entry into the target cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CCR5 Antibody (NB100-714)(1)

Publication using NB100-714

• Abdulkerim Y, Hakan A, Ozdemir O et al. Effects of the Chemokine Receptor 5 (CCR5)-Delta32 Mutation on Hepatitis C Virus-Specific Immune Responses and Liver Tissue Pathology in HCV Infected Patients Hepat Mon [PMID: 25067937] (IF/IHC, Human)

Bioinformatics

• Gene Symbol: CCR5
• Entrez:
  • 1234(Human)