CCR5 Antibody (12D1) [FITC]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, IHC, IHC-Fr
Clone
12D1
Clonality
Monoclonal
Host
Mouse
Conjugate
FITC

Order Details

CCR5 Antibody (12D1) [FITC] Summary

Immunogen
Human native CCR5 protein
Localization
Cell surface
Specificity
Reacts with the N-terminal extracellular domain of CD195. The CC chemokine receptor 5 (CCR5) is a member of the CC-chemokine receptor family, and has the characteristic structure of a 7 transmembrane G protein-coupled receptor (GPCR). CCR5 regulates trafficking and effector functions of memory/effector Th1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands play an important role in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Together with the CD4 binding receptor, CCR5 plays a critical role in HIV entry into the target cells. Moreover, the CCR5 ligands macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta and RANTES act as endogenous inhibitors of HIV infection, making both CCR5 and its chemokine ligands attractive therapeutic targets for HIV infection. Recent studies have also highlighted the role of CCR5 in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer.
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Mouse
Gene
CCR5
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for CCR5 Antibody (12D1) [FITC]

  • C-C CKR-5
  • C-C motif chemokine receptor 5 A159A
  • CCCKR5
  • CC-CKR-5FLJ78003
  • CCR5
  • CCR-5
  • CD195 antigen
  • CD195
  • chemokine (C-C motif) receptor 5
  • chemokine receptor CCR5
  • chemr13
  • CKR5
  • CKR-5
  • HIV-1 fusion coreceptor
  • IDDM22CMKBR5C-C chemokine receptor type 5

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-47759AF350
Alexa Fluor 405 NBP2-47759AF405
Alexa Fluor 488 NBP2-47759AF488
Alexa Fluor 532 NBP2-47759AF532
Alexa Fluor 594 NBP2-47759AF594
Alexa Fluor 647 NBP2-47759AF647
Alexa Fluor 700 NBP2-47759AF700
Alexa Fluor 750 NBP2-47759AF750
Allophycocyanin NBP2-47759APC
Allophycocyanin/Cy7 NBP2-47759APCCY7
Biotin NBP2-47759B
DyLight 350 NBP2-47759UV
DyLight 405 NBP2-47759V
DyLight 488 NBP2-47759G
DyLight 550 NBP2-47759R
DyLight 594 NBP2-47759DL594
DyLight 650 NBP2-47759C
DyLight 680 NBP2-47759FR
DyLight 755 NBP2-47759IR
FITC NBP2-47759F
HRP NBP2-47759H
Janelia Fluor 549 NBP2-47759JF549
Janelia Fluor 646 NBP2-47759JF646
PE NBP2-47759PE
PE/Atto594 NBP2-47759PEATT594
PE/Cy5.5 NBP2-47759PECY55
PE/Cy7 NBP2-47759PECY7
PerCP NBP2-47759PCP

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Contact Information

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Bioinformatics

Gene Symbol CCR5