CCR2 Antibody

Images

 
Immunohistochemistry-Paraffin: CCR2 Antibody [NB100-701] - Paraffin section of mouse spleen.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, Flow, IHC, IHC-P
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

CCR2 Antibody Summary

Immunogen
Synthetic peptide: SHSLFTRSIQELDEGATTPYDYDDGEPC, corresponding to N terminal amino acids 18-45 of the N-terminal domain of Mouse CCR2.
Localization
Cell Membrane
Specificity
Peptide sequence is < 50 % identical to other mouse chemokine receptors in this region.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
CCR2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500
  • Flow Cytometry 1:20
  • Immunohistochemistry 1:125
  • Immunohistochemistry-Paraffin 1:125
Application Notes
IHC-P: Antigen retrieval is not essential but may optimize staining. Optimal dilutions/concentrations should be determined by the end user. All dilutions given are minimums.
Publications
Read Publication using
NB100-701 in the following applications:

  • IHC
    1 publication

Reactivity Notes

Human reported in literature (PMID: 21719683).

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
10mM KHPO4, 0.14M NaCl and 1.0 mg/ml BSA
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CCR2 Antibody

  • C-C chemokine receptor type 2
  • C-C CKR-2
  • CC-CKR-2CKR2B
  • CCR2
  • CCR-2
  • CCR2A
  • CCR2B
  • CD192 antigen
  • CD192
  • chemokine (C-C motif) receptor 2
  • CKR2
  • CKR2A
  • CMKBR2MGC111760
  • FLJ78302
  • MCP-1 receptor
  • MCP-1-RMGC103828
  • MGC168006
  • Monocyte chemoattractant protein 1 receptor
  • monocyte chemotactic protein 1 receptor

Background

CCR2, or C C chemokine receptor type 2, is a receptor for several monocyte chemo attractant proteins (MCP1, MCP3, MCP4) which specifically mediate monocyte chemotaxis. CCR2 transduces such signals by increasing the intracellular level of calcium ions. For example, MCP1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. CCR2 is also an alternative coreceptor with CD4 for HIV1 infection. CCR2 has two isoforms and has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen and thymus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Species: Hu, Mu
Applications: WB, Flow, IHC, IHC-P

Publications for CCR2 Antibody (NB100-701)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: IHC.


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IHC
(1)
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Filter By Species
Mouse
(1)
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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for CCR2 Antibody (NB100-701)

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Blogs on CCR2.

CCR2 or CD192
CCR2 is a receptor for several monocyte chemoattractant proteins (MCP1, MCP3, MCP4) that specifically govern monocyte chemotaxis. CCR2 transduces its downstream signals through increasing intracellular calcium ion levels. For example, MCP1 regulate...  Read full blog post.

CCR2: Affecting Autoimmunity via MCP1 interactions
CCR2, also known as CD192 (cluster of differentiation 192), is a chemokine receptor and is expressed by monocytes, activated T cells, B cells and natural killer cells. This protein is encoded by CCR2 gene in humans. CCR2 gene encodes two protein isofo...  Read full blog post.

MCP1: One Chemoattractant that's Hard to Resist
Monocyte Chemoattractant Protein (MCP1) is a potent monocyte attractant, is a member of the CC chemokine subfamily. MCP1 exerts its effects through binding to G-protein-coupled receptors on the surface of leukocytes targeted for activation and migrati...  Read full blog post.

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Bioinformatics

Gene Symbol CCR2
Entrez
Uniprot