CCR11 Antibody (674144) [Alexa Fluor™ Plus 680]

• Reactivity: Hu
• Clone: 674144
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 680

CCR11 Antibody (674144) [Alexa Fluor™ Plus 680] Summary

• Specificity: Detects human CCR11 in direct ELISAs.
• Isotype: IgM
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CCR11 Antibody (674144) [Alexa Fluor™ Plus 680]

• ACKR4
• CC chemokine receptor-like 1
• C-C CKR-11
• CCBP2CCX CKR
• CC-CKR-11
• CCR11
• CCR11CCR10
• CCRL1
• CCX-CKR
• chemokine (C-C motif) receptor-like 1
• orphan seven-transmembrane receptor, chemokine related
• PPR1
• PPR1cc motif, receptor-like protein 1
• VSHK1
• VSHK1CKR-11

Background

CCR11, also known as CCRL1 and CCX-CKR, is a 45 kDa 7-transmembrane segment protein that is widely expressed on stromal cells. It is a silent receptor that does not induce intracellular calcium signaling, but instead serves as a chemokine scavenger receptor. CCR11 regulates dendritic cell and thymic precursor migration by mediating the clearance of the homeostatic chemokines CCL19, 21, and 25. It is upregulated on some breast cancer cells and on bronchial epithelial cells in pulmonary sarcoidosis. Human CCR11 shares 85% amino acid sequence identity with mouse and rat CCR11.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.