CBLB Antibody


Western Blot: CBLB Antibody [NBP1-49920] - Samples: Whole cell lysate (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-Cbl-b antibody NBP1-49920 used ...read more

Product Details

Reactivity HuSpecies Glossary
Applications WB, IP
1 mg/ml

Order Details

CBLB Antibody Summary

The immunogen for this product maps to a region between residue 932 and 982 of human Cas-Br-M (murine) Ecotropic Retroviral Transforming Sequence b using the numbering given in entry NP_733762.2 (GeneID 868).
Predicted Species
Mouse (100%), Rat (100%), Porcine (100%), Monkey (100%), Rabbit (100%), Primate (100%), Guinea Pig (100%), Bovine (100%), Equine (100%)
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at 4C. Do not freeze.
Tris-citrate/phosphate buffer, pH 7 to 8
0.09% Sodium Azide
1 mg/ml
Immunogen affinity purified

Reactivity Notes

Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, Duckbill platypus, Tasmanian devil, Crab-eating macaque, African elephant, Chinese hamster and Northern white-cheeked gibbon.

Alternate Names for CBLB Antibody

  • Cas-Br-M (murine) ecotropic retroviral transforming sequence b
  • Cas-Br-M (murine) ectropic retroviral transforming sequence b
  • Casitas B-lineage lymphoma proto-oncogene b
  • DKFZp686J10223
  • DKFZp779A0729
  • DKFZp779F1443
  • E3 ubiquitin-protein ligase CBL-B
  • EC 6.3.2
  • EC 6.3.2.-
  • FLJ41152
  • RING finger protein 56
  • RNF56FLJ36865
  • SH3-binding protein CBL-B
  • Signal transduction protein CBL-B


CBLB is an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. May also be involved in EGFR ubiquitination and internalization.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies


Isotype Controls

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Contact Information

Product PDFs


Gene Symbol CBLB

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