Cathepsin S Antibody (248718) [Alexa Fluor™ Plus 555]

• Reactivity: Hu
• Clone: 248718
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor Plus 555

Cathepsin S Antibody (248718) [Alexa Fluor™ Plus 555] Summary

• Specificity: Detects pro and mature forms of human Cathepsin S in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human Cathepsin B, C, D, L, L2/V, X/Z/P, recombinant mouse Cathepsin F, or H is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Rat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Cathepsin S Antibody (248718) [Alexa Fluor™ Plus 555]

• Cathepsin S
• CTSS
• EC 3.4.22
• EC 3.4.22.27
• FLJ50259
• MGC3886

Background

Cathepsin S is a lysosomal cysteine protease of the papain family (1). It plays a major role in the processing of the MHC class II-associated invariant chain (2). It has been implicated in the pathogenesis of several diseases such as Alzheimer’s disease and degenerative disorders associated with the cells of the mononuclear phagocytic system (1). Human Cathepsin S is synthesized as a preproenzyme of 331 amino acid residues consisting a signal peptide (residues 1‑16), a pro region (residues 17‑114), and the mature enzyme (residues 115‑331) (3‑5). Cathepsin S is less abundant in tissues than Cathepsins B, L and H. The highest levels have been found in lymph nodes, spleen, macrophages and other phagocytic cells.

1. Kirschke, H. (2004) in Handbook of Proteolytic Enzymes (ed. Barrett, A.J. et al.) pp. 1104, Academic Press, San Diego.
2. Turk, V. et al. (2001) EMBO J. 20:4629.
3. Shi, G.P. et al. (1992) J. Biol. Chem. 267:7258.
4. Shi, G.P. et al. (1994) J. Biol. Chem. 269:11530.
5. Wiederanders, B. et al. (1992) J. Biol. Chem. 267:13708.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.