Cathepsin L Antibody (204101) [Unconjugated]


Western blot shows 100 ng of Recombinant Human Cathepsin L (Catalog # 952-CY), Recombinant Mouse Cathepsin L (Catalog # 1515-CY), Recombinant Human Cathepsin V (Catalog # 1080-CY), Recombinant Human Cathepsin more
Cathepsin L was detected in immersion fixed paraffin-embedded sections of human kidney using Rat Anti-Human/Mouse Cathepsin L Monoclonal Antibody (Catalog # MAB9521) at 5 µg/mL overnight at 4 °C. Tissue was stained more
Cathepsin L was detected in immersion fixed frozen sections of mouse kidney using Rat Anti-Human/Mouse Cathepsin L Monoclonal Antibody (Catalog # MAB9521) at 8 µg/mL overnight at 4 °C. Tissue was stained using the more

Product Details

Reactivity Hu, MuSpecies Glossary
Applications WB, IHC, IP

Order Details

View Available Formulations
Catalog# & Formulation Size Price

Cathepsin L Antibody (204101) [Unconjugated] Summary

Mouse myeloma cell line NS0-derived recombinant human Cathepsin L
Accession # P07711
Detects human and mouse Cathepsin L in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human Cathepsin B, C, L2, O, S, or X/Z/P is observed. In Western blots, both the pro and active forms of recombinant human and mouse Cathspsin L are recognized.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Western Blot 1 ug/mL
  • Immunohistochemistry 5-25 ug/mL
  • Immunoprecipitation 25 ug/mL
Read Publications using
MAB9521 in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Cathepsin L Antibody (204101) [Unconjugated]

  • Cathepsin L
  • cathepsin L1
  • CATL
  • CTSL
  • CTSL1
  • EC 3.4.22
  • FLJ31037
  • Major excreted protein
  • MEP


Cathepsin L is a lysosomal cysteine protease expressed in most eukaryotic cells. Cathepsin L is known to hydrolyze a number of proteins, including the proform of urokinase-type plasminogen activator, which is activated by Cathepsin L cleavage (1). Cathepsin L has also been shown to proteolytically inactivate alpha 1-antitrypsin and secretory leucoprotease inhibitor, two major protease inhibitors of the respiratory tract (2). These observations, combined with the demonstration of increased Cathepsin L activity in the epithelial lining fluid of the lungs of emphysema patients, have led to the suggestion that the enzyme may be involved in the progression of this disease. Cathepsin L has also been identified as a major excreted protein of transformed fibroblasts, indicating the enzyme could be involved in malignant tumor growth (3).
  1. Goretzki, L. et al. (1992) FEBS Lett. 297:112.
  2. Taggart, C.C. et al. (2001) J. Biol. Chem. 276:33345.
  3. Gottesman, M.M. and F. Cabral (1981) Biochemistry 20:1659.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

Species: Hu
Applications: WB, Simple Western, IHC, IP, KO
Species: Hu
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, Flow-IC
Species: Hu, Mu, Rt
Applications: WB, Simple Western, Flow, ICC/IF, IHC, IHC-P, IM
Species: Mu
Applications: WB, IHC, IP
Species: Hu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Species: Hu
Applications: WB, EM, ELISA, Flow, ICC/IF, IHC, IHC-P
Species: Hu
Applications: WB, IHC, IP, ELISA(Cap), ELISA(Det), Neut, ELISA(Sta)
Species: Hu
Applications: WB, Flow, IHC, IF
Species: Hu, Mu, Bv, Ca, Mk, Rb
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP, MiAr, CyTOF-ready, Flow-IC
Species: Hu
Applications: IHC, IHC-P
Species: Hu
Applications: WB, IHC, IP
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu
Applications: WB, Flow, IP, CyTOF-ready
Species: Hu
Applications: WB, IHC
Species: Hu, Ch
Applications: WB, IHC, IHC-P, IP, KD
Species: Hu
Applications: WB, Simple Western, IHC, IP
Species: Hu
Applications: WB, IHC, IP
Species: Hu

Publications for Cathepsin L Antibody (MAB9521)(9)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: IHC, IHC-P, Western Blot.

Filter By Application
Western Blot
All Applications
Filter By Species
All Species
Showing Publications 1 - 9 of 9.
Publications using MAB9521 Applications Species
CCT complex restricts neuropathogenic protein aggregation via autophagy Nat Commun, 2016;7(0):13821. 2016 [PMID: 27929117] (Western Blot, Human) Western Blot Human
A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy Sci Adv, 2016;2(9):e1601167. 2016 [PMID: 27617292] (Western Blot, Mouse) Western Blot Mouse
Pensa S, Neoh K, Resemann H, Kreuzaler P, Abell K, Clarke N, Reinheckel T, Kahn C, Watson C The PI3K regulatory subunits p55alpha and p50alpha regulate cell death in vivo. Cell Death Differ, 2014;21(9):1442-50. 2014 [PMID: 24902901] (Western Blot, Mouse) Western Blot Mouse
O'Brien J, Martinson H, Durand-Rougely C Macrophages are crucial for epithelial cell death and adipocyte repopulation during mammary gland involution. Development, 2012;139(2):269-75. 2012 [PMID: 22129827] (Western Blot, Mouse) Western Blot Mouse
Kreuzaler PA, Staniszewska AD, Li W, Omidvar N, Kedjouar B, Turkson J, Poli V, Flavell RA, Clarkson RW, Watson CJ Stat3 controls lysosomal-mediated cell death in vivo. Nat. Cell Biol., 2011;13(3):303-9. 2011 [PMID: 21336304] (Western Blot, Mouse) Western Blot Mouse
Lopez-Castejon G, Theaker J, Pelegrin P P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases. J. Immunol., 2010;185(4):2611-9. 2010 [PMID: 20639492] (Western Blot, Human) Western Blot Human
Zeeuwen PL, van Vlijmen-Willems IM, Cheng T The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea. FASEB J., 2010;24(10):3744-55. 2010 [PMID: 20495178] (IHC-P, Mouse) IHC-P Mouse
Parker BS, Ciocca DR, Bidwell BN, Gago FE, Fanelli MA, George J, Slavin JL, Moller A, Steel R, Pouliot N, Eckhardt BL, Henderson MA, Anderson RL Primary tumour expression of the cysteine cathepsin inhibitor Stefin A inhibits distant metastasis in breast cancer. J. Pathol., 2008;214(3):337-46. 2008 [PMID: 17985332] (IHC-P, Mouse) IHC-P Mouse
Cheng T, Hitomi K, van Vlijmen-Willems IM, de Jongh GJ, Yamamoto K, Nishi K, Watts C, Reinheckel T, Schalkwijk J, Zeeuwen PL Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification. J. Biol. Chem., 2006;281(23):15893-9. 2006 [PMID: 16565075] (IHC, Human) IHC Human

Reviews for Cathepsin L Antibody (MAB9521) (0)

There are no reviews for Cathepsin L Antibody (MAB9521). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for Cathepsin L Antibody (MAB9521) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies


Isotype Controls

Other Available Formats

Additional Cathepsin L Products

Bioinformatics Tool for Cathepsin L Antibody (MAB9521)

Discover related pathways, diseases and genes to Cathepsin L Antibody (MAB9521). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for Cathepsin L Antibody (MAB9521)

Discover more about diseases related to Cathepsin L Antibody (MAB9521).

Pathways for Cathepsin L Antibody (MAB9521)

View related products by pathway.

PTMs for Cathepsin L Antibody (MAB9521)

Learn more about PTMs related to Cathepsin L Antibody (MAB9521).

Blogs on Cathepsin L

There are no specific blogs for Cathepsin L, but you can read our latest blog posts.
Recombinant Monoclonal Antibodies

Customers Who Bought This Also Bought

Cathepsin L

Contact Information

Product PDFs


Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.


Review this Product

Be the first to review our Cathepsin L Antibody (204101) [Unconjugated] and receive a gift card or discount.


Gene Symbol CTSL1
Novus 100% Guarantee