Cathepsin K Antibody

Western Blot: Cathepsin K Antibody [NBP1-45460] - Western blot analysis of Cathepsin K with rat kidney tissue lysate.

Product Discontinued

Cathepsin K Antibody Summary

• Immunogen: Synthetic peptide surrounding amino acid 321 of rat cathepsin K (NP_113748).
• Specificity: The antibody detects proform (43 kDa) and the mature form (29 kDa) of cathepsin K.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CTSK
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunoprecipitation
  • Western Blot 0.5-4 ug/ml

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2), 5 mM EDTA, 0.5% BSA, 30% Glycerol
• Preservative: 0.03% Proclin 300
• Concentration: 0.5 mg/ml
• Purity: Affinity purified

Alternate Names for Cathepsin K Antibody

• cathepsin K (pycnodysostosis)
• Cathepsin K
• Cathepsin O
• cathepsin O1
• Cathepsin O2
• Cathepsin X
• CTS02
• CTSK
• CTSO
• CTSO1
• CTSO2
• EC 3.4.22
• EC 3.4.22.38
• MGC23107
• PKND
• PYCD

Background

The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

Publications for Cathepsin K Antibody (NBP1-45460)(1)

Publication using NBP1-45460

• Song J, Jing ZZ, Hu W et al. alpha-Linolenic Acid Inhibits Receptor Activator of NF-kappa B Ligand Induced (RANKL-Induced) Osteoclastogenesis and Prevents Inflammatory Bone Loss via Downregulation of Nuclear Factor-KappaB-Inducible Nitric Oxide Synthases (NF-kappa B-iNOS) Signaling Pathways. Med Sci Monit. 2017-10-24 [PMID: 29061958] (WB, Mouse)

Bioinformatics

• Gene Symbol: CTSK
• Entrez:
  • 1513(Human)
  • 13038(Mouse)
  • 29175(Rat)
• Uniprot:
  • NP_113748(Rat)