Cathepsin D Native Protein

Product Discontinued

Cathepsin D Native Protein Summary

• Description: Native Cathepsin D
  
  

  Source:Human liver
  Amino Acid Sequence:(P07339)

• Source: Human liver
• Protein/Peptide Type: Native Protein
• Gene: CTSD
• Purity: >95%, by SDS-PAGE

Applications/Dilutions

• Dilutions:
  • Bioactivity
  • SDS-Page
• Application Notes: Unit Definition: >300 units/mg protein. One unit is defined as the amount of enzyme that digests hemoglobin releasing peptides which are soluble in 10% TCA. The reaction is measured by an increase of an A280 of 1.0 per 60 minutes at 37C. Substrate: acid denatured hemoglobin (0.2% in reaction mixture). Buffer: 100 mM formate. pH 3.3.
  Specific activity: 365 units/mg

Packaging, Storage & Formulations

• Storage: Store at -80C. Avoid freeze-thaw cycles.
• Buffer: Lyophilized from 2 mM sodium phosphate (pH 6.5).
• Concentration: Lyoph
• Purity: >95%, by SDS-PAGE
• Reconstitution Instructions: Reconstitute the vial in H2O to 0.1 - 1 ug/ul. Aliquot and refreeze at -80C immediately for long-term storage.

Alternate Names for Cathepsin D Native Protein

• cathepsin D (lysosomal aspartyl protease)
• Cathepsin D
• CPSD
• CTSD
• EC 3.4.23
• EC 3.4.23.5
• lysosomal aspartyl peptidase
• lysosomal aspartyl protease
• MGC2311
• neuronal 10

Background

Cathepsin D is an estrogen-regulated protein associated with tissue breakdown. Levels of cathepsin D have been positively correlated with recurring breast cancers of both node negative and node positive types. Additionally cathepsin D has been associated with amyloid formation in Alzheimer's plaques. As cathepsin D activity is increased by cigarette smoke, the enzyme may contribute to lung tissue damage in smokers.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: CTSD