CARD12 Antibody [DyLight 550]


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Product Details

Reactivity Hu, MuSpecies Glossary
Applications ICC/IF, IHC, IHC-P
DyLight 550

CARD12 Antibody [DyLight 550] Summary

A synthetic peptide made to an internal portion of the human CARD12 protein (between residues 600-700) [UniProt Q9NPP4]
Cytoplasm. Note: Cytoplasmic filaments.
Immunogen affinity purified
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  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
This CARD12 antibody is useful for Immunocytochemistry/Immunofluorescence and IHC-paraffin embedded sections. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.

Reactivity Notes

Human and mouse.

Packaging, Storage & Formulations

Store at 4C in the dark.
50mM Sodium Borate
0.05% Sodium Azide
Immunogen affinity purified


Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for CARD12 Antibody [DyLight 550]

  • CARD12leucine rich repeat and CARD domaincontaining 4
  • caspase recruitment domain family, member 12
  • Caspase recruitment domain-containing protein 12
  • Clan protein
  • CLAN1ipaf
  • CLANCARD, LRR, and NACHT-containing protein
  • CLR2.1
  • Ice protease-activating factor
  • Ipaf
  • NLR family, CARD domain containing 4


CARD12, also known as CLAN, IPAF and CLAN1 is a member of the CED4 family of proteins. The CED4/Apaf-1 proteins are critical regulators of apoptosis and NF-kappaB signaling pathways, and CARD12 is no exception. CARD12 has been implicated in coordination of downstream activation of both apoptotic and inflammatory signaling pathways (PMID: 11374873). Additionally, CARD12 has shown to coprecipitate with caspase 1, an enzyme that participates in both the signaling of apoptosis and cytokine processing, further demonstrating its integral role in programmed cell death (PMID: 11374873). As part of the nucleotide-binding site and leucine-rich repeat (NBS-LRR) proteins, CARD12 is known to be an important regulator of caspase-1 activation via an ATP/dATP nucleotide-binding pocket (PMID: 15882992). CARD12 has four known isoforms. Isoform 1 is highly expressed in lung, followed by leukocytes (especially monocytes), lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Although it is expressed ubiquitously, Isoform 2 is more prominent at the highest levels in lung and spleen. Isoform 4 can only been found in the brain.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP1-78979AF350
Alexa Fluor 405 NBP1-78979AF405
Alexa Fluor 488 NBP1-78979AF488
Alexa Fluor 532 NBP1-78979AF532
Alexa Fluor 594 NBP1-78979AF594
Alexa Fluor 647 NBP1-78979AF647
Alexa Fluor 700 NBP1-78979AF700
Alexa Fluor 750 NBP1-78979AF750
Biotin NBP1-78979B
DyLight 350 NBP1-78979UV
DyLight 405 NBP1-78979V
DyLight 488 NBP1-78979G
DyLight 550 NBP1-78979R
DyLight 594 NBP1-78979DL594
DyLight 650 NBP1-78979C
DyLight 680 NBP1-78979FR
DyLight 755 NBP1-78979IR
FITC NBP1-78979F
Janelia Fluor 549 NBP1-78979JF549
Janelia Fluor 646 NBP1-78979JF646

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Gene Symbol NLRC4