CARD12 Products

Antibodies
CARD12 Antibody
CARD12 Antibody
NB100-56142
Species: Hu, Mu
Applications: WB, IHC, IHC-Fr, IHC-P, IP
Host: Rabbit Polyclonal
CARD12 Antibody
CARD12 Antibody
NBP1-78979
Species: Hu, Mu
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
CARD12 Antibody
CARD12 Antibody
NBP1-78980
Species: Hu, Mu
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
CARD12 Overexpression Lysate ...
CARD12 Overexpression Lysate (Native)
NBP2-06545
Applications: WB
Proteins
Recombinant Human CARD12 Prot ...
Recombinant Human CARD12 Protein
H00058484-Q01
Species: Hu
Applications: WB, ELISA, PA
CARD12 Recombinant Protein An ...
CARD12 Recombinant Protein Antigen
NBP2-13660PEP
Species: Hu
Applications: AC
RNAi
CARD12 RNAi
CARD12 RNAi
H00058484-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Ipaf (also known as Clan/CARD12) is a CARD domain containing protein. CARD (caspase-associated recruitment domain) proteins are key regulators of cell death, cell survival and cytokine production (reviewed in Damiano and Reed, 2004). In general CARD proteins are implicated in host defense against infection, environmental stress or cellular damage. CARD domains are found in the N-terminal pro-domains of certain caspases, a family of apoptotic and pro-inflammatory proteases, as well as in a diversity of other proteins including Ipaf/Clan/CARD12. CARD domains are homotypic protein interaction motifs that enable networks of proteins to communicate via CARD-CARD interactions. There are at least three major signaling pathways in which CARD proteins act: (1) Regulation of caspase activation in the context of apoptosis (2) Regulation of caspase activation in the context of inflammation (3) Regaultion of NF-kB activation in the context of innate or adaptive immune responses. As there is significant crosstalk between pathways that lead to caspase-mediated apoptosis or inflammation and pathways that result in NF-kB activation, it is logical that similar protein modules such as CARD domains are found repeatedly in proteins from all three pathways. Ipaf plays a role in regulating caspase-1 activity, which in turn mediates the maturation of inflammatory cytokines IL-1b and IL-18 (reviewed in Lu et al, 2005). In transfected cells, Ipaf has been shown to directly interact with procaspase-1 and induce proteolytic activation of procaspase-1 in transfected cells. On the flip side, macrophages from IPAF deficient mice failed to activate caspase-1 in response to Salmonella typhimurium infection underscoring the importance of IPAF in vivo. IPAF also interact with the pro-apoptotic adaptor protein ASC and co-expression of IPAF with ASC has been shown to induce NF-kB activation and apoptosis.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Product By Gene ID 58484
Alternate Names
  • Caspase recruitment domain-containing protein 12
  • Clan protein
  • caspase recruitment domain family, member 12
  • Ipaf
  • CLR2.1
  • CARD12leucine rich repeat and CARD domaincontaining 4
  • CLAN1ipaf
  • CLANCARD, LRR, and NACHT-containing protein
  • Ice protease-activating factor
  • NLR family, CARD domain containing 4

Research Areas for CARD12

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Immunology
Innate Immunity

PTMs for CARD12

Learn more about PTMs related to CARD12.

Cleavage
Phosphorylation
Nitrosylation
Ubiquitination

Bioinformatics Tool for CARD12

Discover related pathways, diseases and genes to CARD12. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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