Canine IL-8/CXCL8 DuoSet ELISA, 15 Plate

• Reactivity: Ca
• Applications: ELISA
• Conjugate: Biotin

Canine IL-8/CXCL8 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: CXCL8

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Canine IL-8/CXCL8 DuoSet ELISA, 15 Plate

• 3-10C
• AMCF-I
• C-X-C motif chemokine 8
• CXCL8
• CXCL8SCYB8
• Emoctakin
• GCP1
• GCP-1TSG-1
• IL8
• IL-8
• interleukin 8
• K60
• LAI
• LECT
• LUCT
• LYNAP
• MDNCF
• MDNCFb-ENAP
• member 8
• MONAP
• MONAPGCP1
• NAF
• NAP1
• NAP-1NAP1
• NCF
• Neutrophil-activating protein 1
• Protein 3-10C
• T cell chemotactic factor
• T-cell chemotactic factor
• TCF
• TSG1

Background

Interleukin-8 (IL-8), also known as CXCL8, is a chemokine that is upregulated at sites of inflammation where it promotes neutrophil infiltration and activation. IL-8 can form homodimers and heterodimers with CXCL4/PF4. Its bioactivity is regulated by proteolytic truncations, citrullination, and the decoy receptor DARC. IL-8 signals through CXCR1/IL-8 RA, which is also used by CXCL6, and through CXCR2/IL-8 RB, which is used by multiple CXC chemokines. IL-8 also binds to Serpin A1/alpha-1 Antitrypsin which prevents IL-8 interaction with CXCR1.

Publications for CXCL8/IL-8 (DY1608)(5)

Publications using DY1608

• Jung, K;Ku, JY;Kwon, JS;Won, G;Yoon, H;Oh, SI;Kim, MH;Kim, C;Yoon, JS; IFN-?/TNF-? Synergism Induces Pro-Inflammatory Cytokine and Chemokine Production by In Vitro Canine Keratinocytes Veterinary sciences 2025-01-14 [PMID: 39852930] (Canine)
• M Pelst, C Höbart, H de Rooster, B Devriendt, E Cox Immortalised canine buccal epithelial cells' CXCL8 secretion is affected by allergen extracts, Toll-like receptor ligands, IL-17A and calcitriol Veterinary research, 2022-09-13;53(1):72. 2022-09-13 [PMID: 36100942] (Canine)
• H Yang, W Kim, J Bae, H Kim, S Kim, J Choi, J Park, DI Jung, H Koh, D Yu Effects of irradiation and leukoreduction on down regulation of CXCL-8 and storage lesion in stored canine whole blood J. Vet. Sci., 2019-01-31;0(0):. 2019-01-31 [PMID: 30541183] (Canine)
• Costa-Pereira C, Moreira M, Soares R, Marteleto B, Ribeiro V, Franca-Dias M, Cardoso L, Viana K, Giunchetti R, Martins-Filho O, Araujo M One-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis. BMC Vet Res, 2015-04-11;11(0):92. 2015-04-11 [PMID: 25880646] (Canine)
• Ishijima N, Suzuki M, Ashida H, Ichikawa Y, Kanegae Y, Saito I, Boren T, Haas R, Sasakawa C, Mimuro H BabA-mediated adherence is a potentiator of the Helicobacter pylori type IV secretion system activity. J. Biol. Chem., 2011-05-19;286(28):25256-64. 2011-05-19 [PMID: 21596743] (Canine)

Bioinformatics

• Gene Symbol: CXCL8