Caldesmon/CALD1 Antibody (RM396)

Western Blot: Caldesmon/CALD1 Antibody (RM396) [NBP3-23459] - Western Blot of HeLa cells lysate using Clone RM396) at a 1:100 dilution.

Immunohistochemistry-Paraffin: Caldesmon/CALD1 Antibody (RM396) [NBP3-23459] - Immunohistochemical staining of formalin fixed and paraffin embedded human colon tissue section using Clone RM396) at a 1:100 dilution.

• Reactivity: Hu
• Applications: WB, IHC
• Clone: RM396
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated

Caldesmon/CALD1 Antibody (RM396) Summary

• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: A peptide corresponding to human Caldesmon/CALD1 (Uniprot#: Q05682)
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: CALD1
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:100-1:200
  • Western Blot 1:100-1:1000

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: 50% Glycerol/PBS, 1% BSA
• Preservative: 0.09% Sodium Azide
• Purity: Protein A purified

Notes

[Public Notes]

Alternate Names for Caldesmon/CALD1 Antibody (RM396)

• CAD
• CALD1
• caldesmon 1
• Caldesmon
• CDM
• CDMH-CAD
• HCAD
• LCAD
• L-CAD
• MGC21352
• NAG22

Background

Caldesmon is a smooth muscle and nonmuscle regulatory protein that interacts with actin, myosin, tropomyosin, and calmodulin (1,2). Smooth muscle caldesmon is an elongated molecule with a calmodulin, tropomyosin, and actin-binding region at the C-terminus and a myosin-binding domain at the N-terminus (3). Caldesmon stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, caldesmon inhibits the actomyosin ATPase by binding to F-actin. This inhibition is reduced by calcium-calmodulin and is promoted by tropomyosin (4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CALD1