Cadherin-11 Antibody (667039) [Alexa Fluor® 750]

Images

 
There are currently no images for Cadherin-11 Antibody (FAB17901S).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
667039
Clonality
Monoclonal
Host
Mouse
Conjugate
Alexa Fluor 750
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.

Cadherin-11 Antibody (667039) [Alexa Fluor® 750] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Cadherin-11
Phe23-Thr617
Accession # AAA35622
Specificity
Detects human Cadherin-11 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) Cadherin-4, -6, -8, -12, -13,
-17, rhE-Cadherin, rhN-Cadherin, rhP-Cadherin, or rhVE-Cadherin is observed.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
CDH11
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 0.25-1 ug/10^6 cells
Application Notes
Flow Cytometry: Please use 0.25-1 ug of conjugated antibody per 10e6 cells.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Buffer
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Preservative
0.09% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Cadherin-11 Antibody (667039) [Alexa Fluor® 750]

  • CAD11OSF-4
  • cadherin 11, type 2, OB-cadherin (osteoblast)
  • Cadherin11
  • Cadherin-11
  • CDH11
  • CDHOB
  • OB
  • OB-Cadherin
  • Osteoblast cadherin

Background

Cadherin-11, also known as OB-Cadherin, is a 120 kDa member of the classical Cadherin family of calcium-dependent homophilic adhesion proteins. Cadherins are involved in multiple processes including embryonic development, cell migration, and maintenance of epithelial integrity (1). Cadherin-11 is expressed in embryonic mesodermal tissues and contributes to the morphogenesis of the nervous and skeletal systems (2-4). It is expressed on osteoblasts in the adult where it promotes the differentiation of both osteoblasts and chondrocytes (5). Cadherin-11 is up‑regulated on breast cancer and prostate cancer cells which preferentially metastasize to bone (6, 7). It facilitates this metastasis via homophilic adhesion to bone marrow stroma and osteoblast-expressed Cadherin-11 (6‑8). In the synovium, Cadherin‑11 supports adhesion between synoviocytes but promotes cell invasion in synovitis and rheumatoid arthritis (9, 10). Its up‑regulation in the vasculature following injury contributes to intimal hyperplasia by inducing smooth muscle cell migration and proliferation (11). In the nervous system, Cadherin-11 interacts with FGF R1 to promote neurite extension from spinal cord explants (12). Mature human Cadherin‑11 consists of a 564 amino acid (aa) extracellular domain (ECD) with five tandem Cadherin repeats, a 23 aa transmembrane segment, and a 156 aa cytoplasmic domain (13, 14). Within the ECD, human Cadherin-11 shares 97% and 98% aa sequence identity with mouse and rat Cadherin‑11, respectively. An 80 kDa portion of the Cadherin‑11 ECD can be shed by proteolytic cleavage, and this fragment competes with the full length molecule for cell adhesion (3, 15). Alternate splicing of human Cadherin-11 generates an 85 kDa isoform with substituted transmembrane and cytoplasmic regions (14, 15).
  1. Pokutta, S. and W.I. Weis (2007) Annu. Rev. Cell Dev. Biol. 23:237.
  2. Kimura, Y. et al. (1995) Dev. Biol. 169:347.
  3. McCusker, C. et al. (2009) Mol. Biol. Cell 20:78.
  4. Clendenon, S.G. et al. (2009) Dev. Dyn. 238:1909.
  5. Kii, I. et al. (2004) J. Bone Mineral Res. 19:1840.
  6. Tamura, D. et al. (2008) Int. J. Oncol. 33:17.
  7. Chu, K. et al. (2008) Mol. Cancer Res. 6:1259.
  8. Huang, C.-F. et al. (2010) Cancer Res. 70:4580.
  9. Valencia, X. et al. (2004) J. Exp. Med. 200:1673.
  10. Kiener, H.P. et al. (2009) Arthritis Rheum. 60:1305.
  11. Monahan, T.S. et al. (2007) J. Vasc. Surg. 45:581.
  12. Boscher, C. and R.-M. Mege (2008) Cell. Signal. 20:1061.
  13. Tanihara, H. et al. (1994) Cell Adhes. Commun. 2:15.
  14. Okazaki, M. et al. (1994) J. Biol. Chem. 269:12092.
  15. Kawaguchi, J. et al. (1999) J. Bone Mineral Res. 14:764.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

NBP2-34260
Species: Hu, Mu, Po, Bv, Rb
Applications: WB, Flow, ICC/IF, IHC-Fr, IHC-P, IP, PAGE
MAB1419
Species: Hu, Rt
Applications: IHC, CyTOF-ready, ICC, ICFlow
AF497
Species: Mu
Applications: WB, Flow, IHC, CyTOF-ready
NB300-109
Species: Hu, Mu, Rt, Dr, I, Ma
Applications: WB, Simple Western, ICC/IF, IHC, IHC-Fr, IHC-P, ICC, IHC-FrFl
NB100-1533
Species: Hu, Mu, Po, Sh
Applications: WB, ICC/IF, IHC, IHC-P, PEP-ELISA
NBP2-35216
Species: Hu
NBP2-42388
Species: Hu
Applications: WB, IHC, IHC-P, KD
NB300-141
Species: Hu, Mu, Rt, Po, Bv, Eq
Applications: WB, Simple Western, ICC/IF, IHC, IHC-Fr, IHC-P
NBP1-46535
Species: Hu, Mu, Rt, Rb, Xp, Ze
Applications: WB, IHC, IHC-Fr, IHC-P
NBP1-48309
Species: Hu, Mu, Rt
Applications: WB, Simple Western, Flow, ICC/IF, IHC, IHC-P, IP, Flow-IC
NBP2-38770
Species: Hu, Mu
Applications: WB, IHC, IHC-P
NBP2-42378
Species: Hu
Applications: WB, IHC, IHC-P
NB110-74751
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P

Publications for Cadherin-11 Antibody (FAB17901S) (0)

There are no publications for Cadherin-11 Antibody (FAB17901S).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for Cadherin-11 Antibody (FAB17901S) (0)

There are no reviews for Cadherin-11 Antibody (FAB17901S). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for Cadherin-11 Antibody (FAB17901S) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Additional Array Products

Bioinformatics Tool for Cadherin-11 Antibody (FAB17901S)

Discover related pathways, diseases and genes to Cadherin-11 Antibody (FAB17901S). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for Cadherin-11 Antibody (FAB17901S)

Discover more about diseases related to Cadherin-11 Antibody (FAB17901S).
 

Pathways for Cadherin-11 Antibody (FAB17901S)

View related products by pathway.

PTMs for Cadherin-11 Antibody (FAB17901S)

Learn more about PTMs related to Cadherin-11 Antibody (FAB17901S).

Blogs on Cadherin-11.

Epithelial-Mesenchymal Transition (EMT) Markers
Epithelial-Mesenchymal Transition (EMT) is the trans-differentiation of stationary epithelial cells into motile mesenchymal cells. During EMT, epithelial cells lose their junctions and apical-basal polarity, reorganize their cytoskeleton, undergo a...  Read full blog post.

Customers Who Bought This Also Bought

Cadherin-11
1790-CA-050

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our Cadherin-11 Antibody (667039) [Alexa Fluor® 750] and receive a gift card or discount.

Bioinformatics

Gene Symbol CDH11
Entrez
Uniprot