Cactin Antibody

Western Blot: Cactin Antibody [NBP1-70775] - analysis of Cactin. Lanes 1 and 2 show human heart tissue lysate probed with pre-immune sera (1:5000) and Cactin polyclonal antibody (7 ug/ml), respectively.

Immunohistochemistry-Paraffin: Cactin Antibody [NBP1-70775] - staining of human brain using Cactin polyclonal antibody at 5 ug/ml.

• Reactivity: Hu, Po, Bv, Ca, Pm, Pm, Ma-Op, RM
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

Cactin Antibody Summary

• Description: Novus Biologicals Rabbit Cactin Antibody (NBP1-70775) is a polyclonal antibody validated for use in IHC and WB. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: A portion of amino acid 460-510 of human Cactin was used as the immunogen.
• Predicted Species: Chimpanzee (100%), Opossum (100%), Rhesus Macaque (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CACTIN
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 5 ug/ml
  • Western Blot 5-7 ug/ml

Reactivity Notes

Predicted to react with Bacteria, Mosquito, Mouse, Pufferfish, Rat, Wild Turkey, Zebrafish.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS containing 0.05% BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Protein A purified

Alternate Names for Cactin Antibody

• C19orf29
• cactin homolog
• cactin
• cactin, spliceosome C complex subunit
• chromosome 19 open reading frame 29
• FLJ17482
• FLJ59622
• fSAPc
• functional spliceosome-associated protein c
• NY REN 24 antigen
• NY-REN-24 antigen
• NY-REN-24

Background

Cactin is a novel negative regulator of TLR signaling and reveals its capacity to target MHC Class III genes at the molecular and functional level. It is localized to the nucleus, which is critical for manifesting its inhibitory effects on TLR signaling. Experimental evidences show overexpression of Cactin suppresses TLR-induced activation of NF-kB and interferon-regulatory factor transcription factors and induction of TLR-responsive genes. It is also reported Cactin interacts with IkB-like protein and targets other proteins that are encoded by genes in the MHC Class III region of chromosome 6.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CACTIN
• Uniprot:
  • Q8WUQ7(Human)