Cactin Antibody

Images

 
Western Blot: Cactin Antibody [NBP1-70775] - analysis of Cactin. Lanes 1 and 2 show human heart tissue lysate probed with pre-immune sera (1:5000) and Cactin polyclonal antibody (7 ug/ml), respectively.
Immunohistochemistry-Paraffin: Cactin Antibody [NBP1-70775] - staining of human brain using Cactin polyclonal antibody at 5 ug/ml.

Product Details

Summary
Reactivity Hu, Po, Bv, Ca, PmSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

Cactin Antibody Summary

Immunogen
A portion of amino acid 460-510 of human Cactin was used as the immunogen.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CACTIN
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 5-7 ug/ml
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 5 ug/ml

Reactivity Notes

Cross reacts with Chimpanzee, Cow, Dog, Human, Opossum, Rhesus Monkey and Wild Pig. Predicted to react with Bacteria, Mosquito, Mouse, Pufferfish, Rat, Wild Turkey, Zebrafish. The amino acid sequence used as immunogen is 100% homologous in human, chimpanzee, rhesus monkey, 88% homologous in wild pig, 82% homologous in dog, cow, opossum, 64% homologous in mouse, rat, wild turkey, mosquito and 47% homologous in zebrafish, pufferfish, and bacteria.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS containing 0.05% BSA
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Alternate Names for Cactin Antibody

  • C19orf29
  • cactin homolog
  • cactin
  • cactin, spliceosome C complex subunit
  • chromosome 19 open reading frame 29
  • FLJ17482
  • FLJ59622
  • fSAPc
  • functional spliceosome-associated protein c
  • NY REN 24 antigen
  • NY-REN-24 antigen
  • NY-REN-24

Background

Cactin is a novel negative regulator of TLR signaling and reveals its capacity to target MHC Class III genes at the molecular and functional level. It is localized to the nucleus, which is critical for manifesting its inhibitory effects on TLR signaling. Experimental evidences show overexpression of Cactin suppresses TLR-induced activation of NF-kB and interferon-regulatory factor transcription factors and induction of TLR-responsive genes. It is also reported Cactin interacts with IkB-like protein and targets other proteins that are encoded by genes in the MHC Class III region of chromosome 6.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol CACTIN
Uniprot