C1qR1/CD93 Antibody (R139) [Biotin]

Product Discontinued

C1qR1/CD93 Antibody (R139) [Biotin] Summary

• Immunogen: The immunogen for this antibody was CD93.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: CD93
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Flow Cytometry 1:10-1:1000
• Application Notes: This R3 antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 1 ug per test. Cell number should be determined empirically but can range from 10^5to 10^8cells/test.
• Readout System:
  • Streptavidin Native Protein NBP2-29367
  • Streptavidin Native Protein NBP2-29370
  • Streptavidin Native Protein NBP2-29371

Reactivity Notes

This antibody is reactive to Human.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: Aqueous buffer, may contain carrier protein/stabilizer (proprietary)
• Preservative: 0.09% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Protein A or G purified

Alternate Names for C1qR1/CD93 Antibody (R139) [Biotin]

• AA4 Antigen
• C1q R1
• C1q receptor 1
• C1q Rp
• C1q/MBL/SPA receptor
• C1qR(P)
• C1qR1
• C1qRp
• CD93 antigenC1qR
• CD93 molecule
• CD93
• CDw93C1QR1
• Collectin Receptor
• Complement component 1 q subcomponent receptor 1
• complement component 1, q subcomponent, receptor 1
• complement component C1q receptor
• dJ737E23.1
• ECSM3
• Ly68
• Matrix-remodeling-associated protein 4
• matrix-remodelling associated 4
• MXRA4

Background

The monoclonal antibody R3 recognizes human CD93, also known as C1qRp. The glycoprotein CD93 binds to C1q, the subunit of the complement protein, mannose binding lectin and pulmonary surfactant protein A. CD93 is predicted to play a role in the clearance of apoptotic cells. Expression of CD93 is confined to myeloid cells with higher expression on monocytes than neutrophils, eosinophils, platelets and endothelial cells. Expression on DCs is downregulated upon maturation. Additionally, CD93 has been shown to define an early bone marrow stem cell population of hematopoietic and hepatic precursors. The R3 antibody has been shown to have activating function by increasing phagocytosis when presented in an immobilized state and inhibitory functions when presented in a soluble state. CD93 can be shed from the cell surface. This phenomenon can be measures using R3 antibody as detection with R139 as capture to detect soluble CD93 by ELISA. The epitope for R3 lies in the CRD domain.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CD93