BMX Antibody (1C6)

Western Blot: BMX Antibody (1C6) [NBP1-47489] - Western blot analysis using BMX mAb against BMX-hIgGFc transfected HEK293 cell lysate.

• Reactivity: Hu
• Applications: WB, ELISA
• Clone: 1C6
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated

BMX Antibody (1C6) Summary

• Description: Novus Biologicals Mouse BMX Antibody (1C6) (NBP1-47489) is a monoclonal antibody validated for use in WB and ELISA. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Purified recombinant fragment of human BMX expressed in E. Coli.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: BMX
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA 1:10000
  • Western Blot 1:500-1:2000
• Theoretical MW: 78 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Hunam

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Ascites
• Preservative: 0.03% Sodium Azide
• Purity: Unpurified

Alternate Names for BMX Antibody (1C6)

• BMX non-receptor tyrosine kinase
• BMX
• Bone marrow tyrosine kinase gene in chromosome X protein
• EC 2.7.10
• EC 2.7.10.2
• Epithelial and endothelial tyrosine kinase
• ETK
• Etk/Bmx cytosolic tyrosine kinase
• ETKcytoplasmic tyrosine-protein kinase BMX
• NTK38 tyrosine kinase
• NTK38
• PSCTK2
• PSCTK3

Background

Etk (epithelial and endothelial tyrosine kinase) is a member of the TEC family of non-receptor protein tyrosine kinase which includes Btk, Itk and TEC. Etk is composed of a pleckstrin domain, an SH3 and SH2 domain and a catalytic kinase domain (1). Etk is implicated in cell adhesion, migration, proliferation, survival as well as signal transduction (2). In PCA, Etk activation by IL-6 is mediated by PI3-K (3). It as also been shown in TNF-induced angiogenesis, TNF activates Etk through TNFR2 (4). Additionally, in the AR pathway, ETtk, FAK and Src form a complex. FAK activates Src which in turn activates Etk by phosphorylating Etk tyrosine residue 566 (5).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: BMX