BMP-6 Antibody (74219.11)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, B/N
Clone
74219.11
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.5 mg/ml

BMP-6 Antibody (74219.11) Summary

Immunogen
Recombinant full length protein (Human) expressed in CHO cells.
Localization
Secreted
Specificity
This shows less than 5 % cross-reactivity with recombinant human BMP5 and BMP7 and no cross-reactivity with recombinant human BMP2 and BMP4 under reducing conditions.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
BMP6
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1-2 ug/ml
  • ELISA 1:100-1:2000
  • Block/Neutralize
Application Notes
ELISA: Use at a concentration of 0.5 - 1.0 ug/ml. The detecton limit for recombinant human BMP-6 is approximately 6.2 ng/well.Inhib: Use at a concentration of 1 - 3 ug/ml.WB: Use at a concentration of 1 - 20 ug/ml. The detection limit for recombinant human BMP6 is approximately 20 ng/lane under non-reducing conditions.Anti-Human Bone Morphogenetic Protein 6 (BMP6) is measured by its ability to neutralize the bioactivity of BMP6 in osteoblast MC3T3-E1 cells. Recombinant human BMP6 is added to various concentrations of the antibody for 1 hour at 37. This antibody has neutralizing activity at 0.5-2 ug/ml in an assay using ATDC-5 cells, which indicates that it has specificity to an epitope of the target which neutralizes its functional activity.
Control
BMP-6 Overexpression Lysate

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS and 5% Trehalose
Preservative
No Preservative
Concentration
0.5 mg/ml
Purity
Protein G purified

Alternate Names for BMP-6 Antibody (74219.11)

  • BMP6
  • BMP-6
  • bone morphogenetic protein 6
  • vegetal related growth factor (TGFB-related)
  • vegetal-related (TGFB related) cytokine
  • VG-1-R
  • VG-1-related protein
  • Vg1-related sequence
  • VGR
  • VGR1
  • Vgr-1

Background

Bone Morphogenetic Proteins (BMP) are members of the TGF beta superfamily of cytokines that affect bone and cartilage formation. Similar to other TGF beta family proteins, BMPs are highly conserved across animal species. BMPs are involved in embryogenesis and morphogenesis of various tissues and organs. BMP6 is an autocrine stimulator of chondrocyte differentiation and has been implicated in the development of embryonic kidney and urinary systems. It is involved in liver growth and differentiation, keratinocyte differentiation, and regulation of neuronal tissue development. BMP6 expression is localized to smooth muscle cells of normal cerebral blood vessels, intimal plaques and atherosclerotically changed blood vessels, further suggesting a role as a regulator of developing tissues.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for BMP-6 Antibody (NB120-10859) (0)

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Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NB120-10859AF350
Alexa Fluor 405 NB120-10859AF405
Alexa Fluor 488 NB120-10859AF488
Alexa Fluor 532 NB120-10859AF532
Alexa Fluor 594 NB120-10859AF594
Alexa Fluor 647 NB120-10859AF647
Alexa Fluor 700 NB120-10859AF700
Alexa Fluor 750 NB120-10859AF750
Biotin NB120-10859B
DyLight 350 NB120-10859UV
DyLight 405 NB120-10859V
DyLight 488 NB120-10859G
DyLight 550 NB120-10859R
DyLight 594 NB120-10859DL594
DyLight 650 NB120-10859C
DyLight 680 NB120-10859FR
DyLight 755 NB120-10859IR
FITC NB120-10859F
HRP NB120-10859H

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Bioinformatics Tool for BMP-6 Antibody (NB120-10859)

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Blogs on BMP-6

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Contact Information

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Bioinformatics

Gene Symbol BMP6
Entrez
Uniprot