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507-BP) induces alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line in a dose-dependent manner (orange line). Alkaline phosphatase production elicited by Recombinant Human BMP-6 (300 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human BMP-6 Monoclonal Antibody (Catalog # MAB507). The ND50 is typically 0.5-2.0 µg/mL." class="big_lightbox" target="_blank">
507-BP) induces alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line in a dose-dependent manner (orange line). Alkaline phosphatase production elicited by Recombinant Human BMP-6 (0.15 µg/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human BMP-6 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF507). The ND50 is typically 0.75-3.75 µg/ml in the presence of L-ascorbic acide (50 µg/mL)." class="big_lightbox" target="_blank">
6325-BM) induces alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line in a dose-dependent manner (orange line). Alkaline Phosphatase Production elicited by Recombinant Mouse BMP-6 (0.5 µg/mL) is neutralized (green line) by increasing concentrations of Rat Anti-Mouse BMP-6 Monoclonal Antibody (Catalog # MAB6325). The ND50 is typically 1.5-7.5 µg/mL." class="big_lightbox" target="_blank">
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.
![Immunohistochemistry BMP-6 Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/BMP6_AF507_Immunohistochemistry_17808.jpg)
![Neutralization BMP-6 Antibody (719040) [Unconjugated]](http://images.novusbio.com/images/antibody/BMP6_MAB6325_Block_Neutralize_14855.jpg)
![N/A BMP-6 [Biotin]](http://images.novusbio.com/fullsize/elisa/DATA_BMP6_DY507_ELISA_2077.jpg)
![Bioactivity BMP-6 [Unconjugated]](http://images.novusbio.com/fullsize/protein/BMP-6_507-BP_376.jpg)
![Bioactivity BMP-6 [Unconjugated]](http://images.novusbio.com/fullsize/protein/BMP6_10420BM_3103.jpg)
![Neutralization BMP-6 Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/BMP6_AF507_Block_Neutralize_15120.jpg)
![SDS-Page BMP-6 [Unconjugated]](http://images.novusbio.com/fullsize/protein/BMP-6_507-BP_374.jpg)
![SDS-Page BMP-6 [Unconjugated]](http://images.novusbio.com/fullsize/protein/BMP6_10420BM_3072.jpg)
