BMP-4 Antibody

Immunohistochemistry-Paraffin: BMP-4 Antibody [NBP2-49477] - Staining of human pancreas shows no cytoplasmic positivity in exocrine glandular cells as expected.

Immunohistochemistry-Paraffin: BMP-4 Antibody [NBP2-49477] - Staining of human prostate shows strong cytoplasmic postivity in smooth muscle cells.

Immunohistochemistry-Paraffin: BMP-4 Antibody [NBP2-49477] - Staining of human skeletal muscle shows moderate ctyoplasmic positivity in myocytes.

Immunohistochemistry-Paraffin: BMP-4 Antibody [NBP2-49477] - Staining of human liver shows no cytoplasmic positivity in hepatocytes as expected.

Product Discontinued

BMP-4 Antibody Summary

• Immunogen: This antibody was developed against a recombinant protein corresponding to amino acids: KVAEIQGHAGGRRSGQSHELLRDFEATLLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPELP
• Predicted Species: Mouse (94%), Rat (94%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: BMP4
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:200 - 1:500
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for BMP-4 Antibody

• BMP2B
• BMP-2B
• BMP2B1
• BMP2BMCOPS6
• BMP4
• BMP-4
• Bone morphogenetic protein 2B
• bone morphogenetic protein 4
• DVR4
• MCOPS6
• OFC11
• ZYME

Background

Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Through molecular cloning, 7 BMP cDNAs, designated BMP1 through BMP7, have been recovered. BMP2 through BMP7, are members of the transforming growth factor-beta superfamily of regulatory molecules. Transcript variants utilizing alternative promoters and alternative non-coding first exons have been described in the literature.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for BMP-4 Antibody (NBP2-49477)(1)

Publication using NBP2-49477

• Calniceanu H, Cimpean AM, Raica M et al. RUNX2, BMP4 AND SPARC EXPRESSION IN BONE REGENERATION FOLLOWING BONE SUBSTITUTES BASED SINUS AUGMENTATION HAVE IMPACT ON DENTAL IMPLANTS FAILURE resclinmed.eu 2020-01-01 (IF/IHC, Human)

Bioinformatics

• Gene Symbol: BMP4