BMP-10 Antibody (462732) [Unconjugated]

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Recombinant Human BMP‑10 (Catalog # 2926-BP) induces alkaline phosphatase production in the MC3T3‑E1 mouse preosteoblast cell line in a dose-dependent manner (orange line). Alkaline phosphatase production elicited ...read more

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, B/N
Clone
462732
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

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Catalog# & Formulation Size Price

BMP-10 Antibody (462732) [Unconjugated] Summary

Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human BMP-10
Asn317-Arg424
Accession # O95393
Specificity
Detects human BMP-10 in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human (rh) BMP-1.1, 2, 3, 3b, 4, 5, 6, 7, 9, 15, or the pro region of rhBMP-10 is observed. In direct ELISAs, approximately 90% cross-reactivity with recombinant mouse BMP-10 is observed.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
BMP10
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
  • Neutralization 0.15-0.9 ug/mL
Publications
Read Publications using
MAB2926 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for BMP-10 Antibody (462732) [Unconjugated]

  • BMP10
  • BMP-10
  • bone morphogenetic protein 10
  • MGC126783

Background

Bone morphogenetic protein 10 (BMP-10) is a TGF-beta superfamily member whose expression is restricted to the developing and postnatal heart. It is synthesized as a 424 amino acid (aa) pre-proprotein with a putative 21 aa signal peptide, a 295 aa propeptide, and a 108 aa mature protein. Mature BMP-10 is secreted as a 25 kDa disulfide-linked homodimer. Mature human BMP-10 shares 98% aa sequence identity with mature mouse, and rat BMP-10.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for BMP-10 Antibody (MAB2926)(6)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: ELISA (detection), Neutralization, Western Blot.


Filter By Application
ELISA (detection)
(1)
Neutralization
(3)
Western Blot
(2)
All Applications
Filter By Species
Human
(3)
Mouse
(3)
All Species
Showing Publications 1 - 6 of 6.
Publications using MAB2926 Applications Species
NE Owen, GJ Alexander, S Sen, K Bunclark, G Polwarth, J Pepke-Zaba, AP Davenport, NW Morrell, PD Upton Reduced circulating BMP10 and BMP9 and elevated endoglin are associated with disease severity, decompensation and pulmonary vascular syndromes in patients with cirrhosis EBioMedicine, 2020;56(0):102794. 2020 [PMID: 32454407] (ELISA (detection), Human) ELISA (detection) Human
E Tillet, M Ouarné, A Desroches-, C Mallet, M Subileau, R Didier, A Lioutsko, G Belthier, JJ Feige, S Bailly A heterodimer formed by bone morphogenetic protein 9 (BMP9) and BMP10 provides most BMP biological activity in plasma J. Biol. Chem., 2018;0(0):. 2018 [PMID: 29789425] (Western Blot, Human) Western Blot Human
A mouse model of hereditary hemorrhagic telangiectasia generated by transmammary-delivered immunoblocking of BMP9 and BMP10 Sci Rep, 2016;5(0):37366. 2016 [PMID: 27874028] (Neutralization, Mouse) Neutralization Mouse
Levet S, Ouarne M, Ciais D, Coutton C, Subileau M, Mallet C, Ricard N, Bidart M, Debillon T, Faravelli F, Rooryck C, Feige J, Tillet E, Bailly S BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus. Proc Natl Acad Sci U S A, 2015;112(25):E3207-15. 2015 [PMID: 26056270] (Neutralization, Mouse) Neutralization Mouse
BMP9 and BMP10 are critical for postnatal retinal vascular remodeling. Blood, 2012;119(25):6162-71. 2012 [PMID: 22566602] (Neutralization, Mouse) Neutralization Mouse
Kahr PC, Piccini I, Fabritz L, Greber B, Scholer H, Scheld HH, Hoffmeier A, Brown NA, Kirchhof P Systematic analysis of gene expression differences between left and right atria in different mouse strains and in human atrial tissue. PLoS ONE, 2011;6(10):e26389. 2011 [PMID: 22039477] (Western Blot, Human) Western Blot Human

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Bioinformatics

Gene Symbol BMP10
Uniprot